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Age-dependent immune and lymphatic responses after spinal cord injury [RNA-seq, young]

ABSTRACT: Age-dependent immune and lymphatic responses after spinal cord injury [RNA-seq, young]

PROVIDER: PRJNA843321 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19438481_1.fastq.gz	Fastqsanger.gz
	SRR19438481_2.fastq.gz	Fastqsanger.gz
	SRR19438482_1.fastq.gz	Fastqsanger.gz
	SRR19438482_2.fastq.gz	Fastqsanger.gz
	SRR19438483_1.fastq.gz	Fastqsanger.gz

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Age-dependent immune and lymphatic responses after spinal cord injury [RNA-seq, young]

Project description:We used single-cell RNA sequencing to profile immune cells in the injured spinal cord parenchyma and lymphatic endothelial cells in the spinal cord meninges from young and aged mice. This help us understand the heterogeneity of the immune response after injury and how it is altered in aging. Moreover, the data obtained from the spinal cord meninges provides novel molecular insights into how the meninges may contribute to the repair process.

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Single-cell RNA-sequencing of cells from spinal cord central canal region of young adult and aged mice

Project description:The spinal cord neural stem cell potential is contained within the ependymal cells lining the central canal. This neural stem cell potential is known to decline with age in the mouse. Here, we microdissected and dissociated into single cells the central canal region from the spinal cord of 4 young adult (3-to-4-month old) and 4 aged (18-to-19-month old) C57BL/6J mice to profile the transcriptomes of cells in and around the central canal using 10x Genomics technology.

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