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Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function [CUT&RUN]

ABSTRACT: Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function [CUT&RUN]

PROVIDER: PRJNA844372 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19509400_1.fastq.gz	Fastqsanger.gz
	SRR19509400_2.fastq.gz	Fastqsanger.gz
	SRR19509401_1.fastq.gz	Fastqsanger.gz
	SRR19509401_2.fastq.gz	Fastqsanger.gz
	SRR19509402_1.fastq.gz	Fastqsanger.gz

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Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function [CUT&RUN]

Project description:During development of heart failure, capacity for cardiomyocyte fatty acid oxidation (FAO) and ATP production is progressively diminished contributing to pathologic cardiac hypertrophy and contractile dysfunction. Receptor interacting protein 140 (RIP140; Nrip1) has been shown to function as a transcriptional co-repressor of oxidative metabolism. Here we show that mice lacking RIP140 in striated muscle (strRIP140-/-) have increased expression of a broad array of involved in a broad array of mitochondrial energy metabolism and contractile function in heart and skeletal muscle. strRIP140-/- mice were resistant to the development of pressure overload-induced cardiac hypertrophy, and cardiomyocyte-specific RIP140 deficient (csRIP140-/-) mice were defended against development of heart failure caused by pressure overload combined with myocardial infarction. Genomic enhancers activated by RIP140 deficiency in cardiomyocytes were enriched in binding motifs for transcriptional regulators of mitochondrial function (estrogen-related receptor) and cardiac contractile proteins (myocyte enhancer factor 2). Consistent with a role in the control of cardiac fuel metabolism, loss of RIP140 in heart resulted in augmented triacylglyceride turnover and FA utilization. We conclude that RIP140 functions as a suppressor of a transcriptional regulatory network that controls cardiac fuel metabolism and contractile function, representing a potential therapeutic target for heart failure.

2023-03-30 | GSE205315 | GEO

Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function

Project description:Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function

| PRJNA844371 | ENA

Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function [RNA-seq]

2023-03-30 | GSE205316 | GEO

Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function [RNA-seq]

Project description:Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function [RNA-seq]

| PRJNA844375 | ENA

Receptor Interacting Protein 140 (Nrip1) Controls Cardiac Fuel Metabolism and Function

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-29 | GSE205317 | GEO

Nuclear receptor coregulator NRIP1 R448G modulates T cell gut-homing and Teff:Treg balance to control intestinal inflammation [scRNA-seq]

Project description:Nuclear receptors (NRs) are crucial to integrate metabolite sensing and immune responses in the gut. Nuclear receptor-interacting protein 1 (NRIP1) is an important coregulator of various NRs that has been implicated in inflammatory bowel disease risk, but mechanistic details of how NRIP1 controls NR activities mediating immune homeostasis and inflammation remain elusive. We unveil pleiotropic functions of NRIP1 in distinct CD4+ T cell subsets during intestinal inflammation. We demonstrate that a coding risk variant, NRIP1 R448G, promotes activated CD4+ T cell gut homing and inflammatory cytokine production but impairs regulatory T cell stability, ultimately leading to exacerbated intestinal inflammation. Mechanistically, NRIP1 acts as a corepressor in retinoic acid signaling by modulating VDR (vitamin D receptor) expression and BATF (Basic leucine zipper transcription factor, ATF-like) activity. Our study reveals the impacts of NRIP1 on CD4+ T cells in immune regulation during intestinal inflammation, providing insights into mechanisms by which an NR coregulator controls immune homeostasis and tissue inflammation.

2025-09-03 | GSE236565 | GEO

Nuclear receptor coregulator NRIP1 R448G modulates T cell gut-homing and Teff:Treg balance to control intestinal inflammation [scATAC-Seq]

2025-09-03 | GSE236564 | GEO

Fuel Ethanol Yeast Strains

Project description:Fuel ethanol is now considered a global energy commodity that is fully competitive with gasoline. We have determined genome copy number differences that are common to five industrially important fuel ethanol yeast strains responsible for the production of billions of gallons of fuel ethanol per year from sugarcane. The fuel strains used were CAT1, BG1, PE2, SA1, and VR1 (note that two independent isolates were analyzed, denoted by "-1" and "-2"). These array-CGH data were compared with array-CGH data from nine other non-fuel industrial yeasts: An ale brewing strain ("Sc-ale"), four wine strains (GSY2A, GSY3A, GSY10A, GSY11B), and 4 bakers' yeast strains (GSY149, GSY150, GSY154, GSY155). Our results reveal significant amplifications of the telomeric SNO and SNZ genes only in the fuel strains, whose protein products are involved in the biosynthesis of vitamins B6 (pyridoxine) and B1 (thiamin). We show that these amplifications allow these yeasts to grow efficiently, especially at high sugar concentrations, regardless of the presence or absence of either of the two vitamins. Our results reveal important genetic adaptations that have been selected for in the industrial environment, which may be required for the efficient fermentation of biomass-derived sugars from other renewable feedstocks. A strain or line experiment design type assays differences between multiple strains, cultivars, serovars, isolates, lines from organisms of a single species. Strain Name: fuel strains used for aCGH Strain_or_line_design

2010-06-25 | E-GEOD-13875 | biostudies-arrayexpress

Actinomycetospora sp. C-140 isolate:C-140

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RNA sequence of acute lymphoblastic leukemia cells with NRIP1::PDGFRB fusion

Project description:Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a subset of ALL with a high rate of treatment failure. PDGFRB gene fusion is one of the hallmarks of Ph-like ALL. We identified a novel oncogenic PDGFRB fusion gene, NRIP1::PDGFRB, from a pediatric patient with ALL

2023-12-13 | GSE242858 | GEO

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