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ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent

ABSTRACT: ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent

PROVIDER: PRJNA846786 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19575080_1.fastq.gz	Fastqsanger.gz
	SRR19575080_2.fastq.gz	Fastqsanger.gz
	SRR19575082_1.fastq.gz	Fastqsanger.gz
	SRR19575082_2.fastq.gz	Fastqsanger.gz
	SRR19575083_1.fastq.gz	Fastqsanger.gz

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ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent

Project description:Transcriptional analysis of patient-derived cell lines of adult T-cell leukemia/ lymphoma (ATLL).

2022-10-01 | GSE205653 | GEO

ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent.

Project description:Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell lymphoma associated with the human T-cell lymphotropic virus type 1 virus endemic in regions including Japan, the Caribbean islands, and Latin America. Although progress has been made to understand the disease, survival outcomes with current standard therapy remain extremely poor particularly in acute ATLL, underlying the need for better understanding of its biology and identification of novel therapeutic targets. Recently, it was demonstrated that ATLL of North American-descendent patients (NA-ATLL) is both clinically and molecularly distinct from Japanese-descendent (J-ATLL), with inferior prognosis and higher incidence of epigenetic-targeting mutations compared with J-ATLL. In this study, combined chromatin accessibility and transcriptomic profiling were used to further understand the key transcriptional regulators of NA-ATLL compared with J-ATLL. The ETS1 motif was found to be enriched in chromatin regions that were differentially open in NA-ATLL, whereas the AP1/IRF4 motifs were enriched in chromatin regions more open in J-ATLL. ETS1 expression was markedly elevated in NA-ATLL in both cell line and primary tumor samples, and knockdown of ETS1 in NA-ATLL cells resulted in inhibition of cell growth. CCR4, a previously identified oncogenic factor in ATLL, was found to be a direct ETS1 transcriptional target in NA-ATLL. As such, ETS1 provides an alternate mechanism to enhance CCR4 expression/activity in NA-ATLL, even in the absence of activating CCR4 mutations (CCR4 mutations were identified in 4 of 9 NA-ATLL cases). Taken together, this study identifies ETS1 as a novel dominant oncogenic transcriptional regulator in NA-ATLL.

| S-EPMC9647780 | biostudies-literature

North American Arabidopsis

Project description:Fine-scale Population Structure of North American Arabidopsis Reveals Multiple Sources of Introduction from Across Eurasia

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Canis strain:North American canids

Project description:Canis strain:North American canids Raw sequence reads

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The transcription factor ETS1 is a master regulator of human NK cell differentiation [ChIP-seq]

Project description:Natural killer (NK) cells are innate lymphoid cells that play a critical role in the direct immune defense against tumor cells and pathogens, and additionally have important immune regulatory functions by cytokine secretion. Whereas NK cell biology has been extensively studied in mouse models, transcriptional control of human NK cell differentiation is poorly understood. In this study, we generated ETS1-deficient human embryonic stem cell (hESC) clones using the CRISPR/Cas9 technology. In a complementary approach, we generated ETS1 loss-of-function cord blood hematopoietic stem cells (HSCs) by retroviral transduction of the dominant-negative ETS1 p27 isoform. We show that the transcription factor ETS1 is required for human NK cell differentiation. Transcriptome and ChIP analysis reveal that ETS1 directly regulates expression of several NK cell-linked transcription factors. Also, expression of genes involved in cytokine secretion and cytotoxic activity is ETS1-dependent, whereby these effector functions are decreased in residual NK cells developing from ETS1 loss-of-function cord blood hematopoietic stem cells. Our data show that ETS1 is a critical regulator of human NK cell development and function, and provide important insights in the underlying molecular mechanisms.

2020-10-15 | GSE124103 | GEO

The transcription factor ETS1 is a master regulator of human NK cell differentiation [RNA-seq]

2020-10-15 | GSE105021 | GEO

NABEC (North American Brain Expression Consortium)

Project description:NABEC (North American Brain Expression Consortium)

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NABEC: North American Brain Expression Consortium

Project description:NABEC: North American Brain Expression Consortium

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Project description:Specialized sledge dogs accompanied Inuit dispersal across the North American Arctic

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PB2 and NP of North American H5N1 virus Drive Immune Cell Replication and Systemic infections

Project description:The 2022 North American outbreak of 2.3.4.4b H5N1 avian influenza virus revealed significant mammalian adaptation and pathogenicity, yet mechanisms remain unclear. To address this knowledge gap, we investigated the North American H5N1 strain (GA/W22-145E/22), which demonstrated unique immune cell-mediated systemic dissemination, neuroinvasion, and 100% mortality in ferrets, unlike the non-lethal Eurasian strain (KR/W811/21). Genomic and reverse genetics studies identified PB2478I and NP450N mutations as key determinants of enhanced polymerase activity, immune cell tropism, and pathogenicity. Mutant GA/W22-145E/22 virus carrying PB2478V/NP450S showed complete survival without systemic dissemination. Furthermore, GA/W22-145E/22 demonstrated robust replication in human PBMCs and bovine mammary gland organoids, raising concerns about zoonotic spillover. These findings underscore PB2478I and NP450N as pivotal markers of pathogenicity, emphasizing the urgent need for enhanced surveillance and targeted interventions

2025-08-25 | GSE302017 | GEO

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