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Parenchymal border macrophages regulate CSF flow dynamics [5xFAD]

ABSTRACT: Parenchymal border macrophages regulate CSF flow dynamics [5xFAD]

PROVIDER: PRJNA849229 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19656606_1.fastq.gz	Fastqsanger.gz
	SRR19656606_2.fastq.gz	Fastqsanger.gz
	SRR19656607_1.fastq.gz	Fastqsanger.gz
	SRR19656607_2.fastq.gz	Fastqsanger.gz
	SRR19656608_1.fastq.gz	Fastqsanger.gz

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Parenchymal border macrophages regulate CSF flow dynamics

Project description:Parenchymal border macrophages regulate CSF flow dynamics

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Parenchymal border macrophages regulate CSF flow dynamics [brain]

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Parenchymal border macrophages regulate CSF flow dynamics [5xFAD]

Project description:Microglial cells are the resident macrophages of the brain. Perivascular macrophages (PVM) are also myeloid resident cells that are located at the interface between blood, CSF and brain in the perivascular space. Due to their strategic location and their ability to sample CSF content, we hypothesized that PVM might play a role in CSF flow. Using different fluorescent tracers injected either into the CSF (influx) or the brain parenchyma (efflux) we assessed their spatio-temporal distribution and found that ablation (using clodronate liposomes) or dysfunction (using genetic tools) of PVM alters CSF dynamics and patterns. Using single cell RNA sequencing, we found that PBMs can be divided in two sub-populations, and that one population of PBMs could interact with vascular smooth muscle cells, which allow arterial pulsations and subsequently CSF flow. Interestingly, aging results in altered PVM phenotype, and reversing this phenotype using macrophage specific grown factors reversed some of aging-associated dysfunctions of CSF flow. In summary, our results identify a new role of PVM in CSF flow and open new avenues for therapeutical applications targeting PVM in neurodegenerative diseases such as Alzheimer’s disease.

2022-08-31 | GSE206114 | GEO

Parenchymal border macrophages regulate CSF flow dynamics [CLO depletion]

Project description:Parenchymal border macrophages regulate CSF flow dynamics [CLO depletion]

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Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

Project description:Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

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Parenchymal border macrophages regulate CSF flow dynamics [brain]

2022-08-31 | GSE188283 | GEO

Parenchymal border macrophages regulate CSF flow dynamics [CLO depletion]

2022-08-31 | GSE206115 | GEO

Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

2022-08-31 | GSE188284 | GEO

Parenchymal border macrophages regulate CSF flow dynamics

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-31 | GSE188285 | GEO

Quantitative proteomics of CSF from the Alzheimer's disease mouse model 5xFAD

Project description:The 5xFAD mouse model was used to study the influence of amyloid pathology on the cerebrospinal fluid (CSF) proteome. Therefore, CSF of 7-months old 5xFAD and WT control mice was sampled with an improved collection protocol. Using a minute amount of 5 µL CSF, we applied data dependent and data independent acquisition of the same samples on a Q-Exactive HF mass spectrometer. Comparison of DDA and DIA demonstrate a higher data completeness for DIA. The results show a strong effect on microglia activation exemplified by strongly increased abundances of Trem2 and Cst7. Furthermore, neurodegenerative markers such as neurofilaments and tau (Mapt) were strongly increased for 5xFAD mice.

2025-04-15 | PXD053568 | Pride

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