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Exosomes from VZV-infected neurons

ABSTRACT: Exosomes from VZV-infected neurons

PROVIDER: PRJNA851682 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19779148.fastq.gz	Fastqsanger.gz
	SRR19779149.fastq.gz	Fastqsanger.gz
	SRR19779150.fastq.gz	Fastqsanger.gz
	SRR19779151.fastq.gz	Fastqsanger.gz
	SRR19779152.fastq.gz	Fastqsanger.gz

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HBVAF cells treated with exosomes from VZV-infected neurons

Project description:Exosomes have emerged as essential extracellular signaling vesicles that can deliver proteins and nucleic acids to cells during normal and disease states. Herein, we studied the effects of exosomes produced by VZV-infected human sensory neurons on cerebrovascular cells. Exosomes were isolated from mock- and VZV-infected sensory neurons and protein and nucleic acid was determined by mass spectrometry and Next-Generation Sequencing. Subsequently, mock- and VZV-derived exosomes were applied to primary human brain vascular adventitial fibroblasts (HBVAFs). Overall, exosomes from VZV-infected sensory neurons impacted the pro-inflammatory phenotype of HBVAF cells. The presence of pathogenic exosomes that could circulate throughout the body provides insight into clinical infections.

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Small RNA-seq analysis of exosomes derived from VZV-infected neurons

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HBVAF cells treated with exosomes from VZV-infected neurons

Project description:HBVAF cells treated with exosomes from VZV-infected neurons

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Small RNA-seq analysis of exosomes derived from VZV-infected neurons

Project description:Small RNA-seq analysis of exosomes derived from VZV-infected neurons

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A comparison of gene expression between human dermal fibroblasts and neurons infected by varicella zoster virus

Project description:The cellular transcriptomes of VZV-infected fibroblasts and T-lymphocytes have been reported, but not that of human neurons. In order to determine the transcriptional response of human neurons to VZV infection, we generated 95%-pure populations of neurons from hESC, infected them with recombinant GFP-expressing cell-free VZV, and compared their transcriptome to that of human foreskin fibroblasts infected in parallel, using Agilent microarrays. Applying a twofold-change as the cutoff (p-value<0.05), we observed that transcription of 1654 fibroblast and 340 neuronal genes were upregulated, and 955 fibroblast and 38 neuronal genes were downregulated by VZV infection. 223 of these infection-regulated genes were unique to neurons. Gene ontology enrichment analysis revealed several clusters of genes regulated by VZV in neurons and fibroblasts differed. For example, neurons did not show upregulation of innate immune responses, NF-kappaB, response to stress and DNA repair clusters, in contrast to fibroblasts that upregulated these groups. This is the first study of the response of genetically normal human neurons to viral infection. Two-condition experiment, VZV-GFP23- fibroblast cells vs. fibroblast cells, and VZV-GFP23- neuron cells vs. neuron cells. Data from two biological replicates and two technical replicates were used for each condition.

2014-04-22 | E-GEOD-54385 | biostudies-arrayexpress

A comparison of gene expression between human dermal fibroblasts and neurons infected by varicella zoster virus

2014-04-22 | GSE54385 | GEO

VZV infection of primary keratinocytes

Project description:Our aim was to investigate the interaction between epidermal differentiation and VZV infection. By means of a calcium-induced keratinocyte differentiation model and RNA-seq we show VZV infection has a profound effect on differentiating keratinocytes and hijacks the normal process of epidermal gene expression to generate a signature resembling patterns of gene expression seen in both heritable and acquired skin-blistering disorders. Analysis of the viral transcriptome provides evidence that VZV replication in skin is tightly linked to differentiation and critically, that late viral gene expression is associated with cellular differentiation. The experiment was performed on human primary keratinocytes under four conditions: undifferentiated/uninfected, uninfected/differentiated, VZV-infected/undifferentiated and VZV-infected/differentiated.

2014-05-29 | E-MTAB-1717 | biostudies-arrayexpress

Exosomes from VZV-infected neurons

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-01 | GSE206643 | GEO

RNA-Sequencing data of Varicella Zoster Virus (VZV)-infected human dermal fibroblasts (HDF)

Project description:RNA profiles of HDF infected with various VZV strains were generated by High-throughput sequencing using Illumina Hi-seq 2500

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Total proteome analysis of SK-N-BE2 cells infected with VZV for 48 hours

Project description:To understand the molecular features associated with VZV infection in humans, we applied an orthogonal proteomic approach that assayed the interactions between VZV and its host in the neuroblastoma SK-N-BE2 cell line. First, we infected SK-N-BE2 cells with VZV rOka for 48 hours and analysed the induced proteome changes by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).

2025-07-14 | PXD047273 | Pride

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