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Transcriptomic profiling of SGLT2 inhibitor-treated hypertensive rats

ABSTRACT: Transcriptomic profiling of SGLT2 inhibitor-treated hypertensive rats

PROVIDER: PRJNA853262 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19860000.fastq.gz	Fastqsanger.gz
	SRR19860001.fastq.gz	Fastqsanger.gz
	SRR19860002.fastq.gz	Fastqsanger.gz
	SRR19860003.fastq.gz	Fastqsanger.gz
	SRR19860004.fastq.gz	Fastqsanger.gz

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RNA-Seq analysis of kidney transcriptome profiles in young spontaneously hypertensive rats and revealing the protective effects and potential therapeutic targets of SGLT2 inhibitors in early hypertensive nephropathy

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Transcriptomic profiling of SGLT2 inhibitor-treated hypertensive rats

Project description:Background: Sodium-glucose co-transporter-2 inhibitor (SGLT2i) compounds are antihyperglycemic medications that may improve cardiovascular disease (CVD) and chronic kidney disease prognosis in patients with diabetes mellitus. Methods: We conducted a detailed RNA-sequencing-based exploration of transcriptomic changes in response to empaglifozin in eight different tissuesfrom a rat model of spontaneous hypertension. Corresponding computational analyses were performed to analyze these data. Results: We discovered that empaglifozin exerts potent transcriptomic effects upon various tissues. Empaglifozin therapy may exert effects upon the kidney by impacting aldosterone-regulated sodium resorption, lyosome. The functional enrichment of DEGs indicated empaglifozin may regulate blood pressure, blood glucose, lipid homeostasis and nervous system in SHR. Consistent with our RNA-Seq findings, following 1-month empaglifozin administration, immunofluorescence staining revealed enhanced renal expression of caveolin-1. Conclusions: These findings offer value as a foundation guiding further exploration regarding the effects associated with SGLT2i therapy in the context of hypertension.

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