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The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration [scRNA-seq]

ABSTRACT: The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration [scRNA-seq]

PROVIDER: PRJNA854641 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19909852.fastq.gz	Fastqsanger.gz
	SRR19909853.fastq.gz	Fastqsanger.gz
	SRR19909854.fastq.gz	Fastqsanger.gz
	SRR19909855.fastq.gz	Fastqsanger.gz
	SRR19909856.fastq.gz	Fastqsanger.gz

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Similar Datasets

The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration

Project description:The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration

| PRJNA854636 | ENA

The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration [Spatial]

Project description:The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration [Spatial]

| PRJNA854163 | ENA

The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration [Spatial]

Project description:The adult heart responds to injury by scarring with consequent loss of contractile function, whereas the neonatal heart possesses the ability to regenerate. We compared the immune response to injury in neonatal and adult mouse hearts and discovered that the PD1/PD-L1 immune checkpoint pathway is highly activated in regenerative hearts but is silenced in later life. Deletion of the PD1 receptor or inactivation of its PD-L1 ligand prevented regeneration of neonatal hearts after injury. Our findings reveal a previously unrecognized role of the PD1/PD-L1 pathway in the control of heart regeneration through modulating T cell activity and inflammation following injury and provide new inroads into the control of adult tissue regeneration.

2023-06-01 | GSE207215 | GEO

The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration [scRNA-seq]

2023-06-01 | GSE207289 | GEO

Expression data in PD-L1 positive and PD-L1 negative human melanoma samples

Project description:Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of genes expressed within the tumor microenvironment of PD-L1+ tumors may lead to improved rationally designed treatments. Gene expression profiling was performed on total RNA extracted by laser capture microdissection from 11 archived formalin-fixed paraffin-embedded (FFPE) melanoma specimens, 5 of which were PD-L1 positive and 6 PD-L1 negative. Details of the design, and the gene signatures found are given in the paper associated with this GEO Series: Janis M. Taube, Geoffrey D. Young, Tracee L. McMiller, Shuming Chen, January T. Salas, Theresa S. Pritchard, Haiying Xu, Alan K. Meeker, Jinshui Fan, Chris Cheadle, Alan E. Berger, Drew M. Pardoll, and Suzanne L. Topalian, Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade, Clin Cancer Res 2015, in press.

2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress

Expression data in PD-L1 positive and PD-L1 negative human melanoma samples

2015-05-01 | GSE65041 | GEO

Oleuropein reprograms the immunosuppressive footprint of tumor-associated myeloid cells and enhances PD-L1/PD-1 blockade immunotherapy in cancer

Project description:Therapies based on PD-1/PD-L1 blockade fail in most cancer patients. Here we evaluated the capacities of oleuropein to reprogram tumor-associated immunosuppressive myeloid cells to increase the potency of immunotherapies. Oleuropein caused major global reprogramming of monocytic and granulocytic myeloid-derived suppressor cells and tumor-associated macrophages towards immunostimulatory subsets. Differential quantitative proteomics uncovered activated and down-modulated pathways at high resolution for each subset which regulated major differentiation programs. Oleuropein significantly potentiated the capacities of myeloid cells to activate T-cells and enhanced antitumor properties of PD-1 blockade, either by systemic anti-PD-1 antibody administration, or locally by intratumor antibody delivery with a self-amplifying RNA vector based on Semliki Forest virus. Combination therapies decreased tumor infiltration by immunosuppressive myeloid cells and increased dendritic cell recruitment within draining lymph nodes, leading to systemic antitumor T-cell responses. Potent therapeutic activities were evident in lung cancer models resistant to immunotherapies and in colon cancer models.

2024-12-08 | PXD047616 | JPOST Repository

The PD-1/PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-01 | GSE207290 | GEO

MLLT6 maintains PD‐L1 expression and mediates tumor immune resistance

Project description:MLLT6 maintains PD‐L1 expression and mediates tumor immune resistance

| PRJNA603767 | ENA

Effects of PD-L1 silencing on global transcriptomic changes in tumor

Project description:Cancers evade anti-tumor immunity by up-regulation of immune checkpoint molecules, such as programmed cell death 1 ligand 1 (PD-L1), in response to stimuli, such as interferon-gamma (IFNγ). Expression of PD-L1 within the tumor microenvironment inhibits the anti-tumor immune response by binding the immune checkpoint receptor PD-1 expressed on T cells. Immune checkpoint inhibitors that target the PD-1/PD-L1 pathway are less toxic than standard chemotherapy and produce durable tumor regression and overall survival benefits in several tumors. However, only a small group of patients respond to these therapies, and some of the responders develop acquired resistance. Understanding the effects of PD-L1 silencing on global gene expression is critical to identifying potential immune evasive mechanisms. In this study, we performed transcriptome analysis of PD-L1 knockdown cells and showed that silencing PD-L1 reduced the expression of only a few immunosuppressive genes. Our findings suggest that the identification of novel targets that can control a larger number of immunosuppressive molecules could lead to the development of more effective immunotherapies.

2025-05-07 | GSE285565 | GEO

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