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Methylome analysis for prediction of long and short survival in glioblastoma patients from the Nordic phase 3 trial

ABSTRACT: Methylome analysis for prediction of long and short survival in glioblastoma patients from the Nordic phase 3 trial

PROVIDER: PRJNA855457 | ENA |

REPOSITORIES: ENA

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Methylome analysis for prediction of long and short survival in glioblastoma patients from the Nordic phase 3 trial

Project description:Genome wide DNA methylation profiling of glioblastoma tumor samples from the Nordic randomised, phase 3 trial. For this study samples were selected based on their good prognostic markers (type of surgery, performance status) from three treatment arms (temozolomide (TMZ) vs. hypofractionated radiation 34Gy vs. radiation 60Gy), and based on the MGMT methylation status. From each group half of the patients had short survival and the other half had long survival.

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Effect of Healthy Nordic diet on gene expression in peripheral blood mononuclear cells

Project description:In a randomized controlled dietary intervention study we compared an isocaloric Healthy Nordic diet with the average Nordic diet for influence on peripheral blood mononuclear cells (PBMC) gene expression. We studied obese adults with features of the metabolic syndrom, n=66. There was no significant difference in age, BMI, or gene expression between the groups before the intervention. The intervention lasted for 18-24 weeks.

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A healthy Nordic diet has a beneficial influence on the expression of genes involved in inflammation in subcutaneous adipose tissue

Project description:In a randomized controlled dietary intervention study we compared an isocaloric Healthy Nordic diet with the average Nordic diet for influence on abdominal subcutaneous adipose tisse gene expression. We studied obese adults with features of the metabolic syndrom, n=56. There was no significant difference in age, BMI, or gene expression between the groups before the intervention. The intervention lasted for 18-24 weeks. Gene expression was analyzed using linear mixed-effects models including specific genes as dependent variable, subject identifier as a random effect, and body weight, age, gender, study centre (i.e. also study duration), study group, time-point and study group * time-point interaction as covariates. 128 genes were significantly different regulated by the two diets with a FDR of 24%. TThese genes were overrepresented in pathways related to immune response. I conclusion, a Healthy Nordic diet reduces inflammatory gene expression in abdominal subcutaneous adipose tissue. This could contribute to beneficial influences on lipid metabolism and cardiovascular disease.

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The Nordic Centre of Excellence Programme in Molecular Medicine

Project description:The Nordic Centre of Excellence Programme in Molecular Medicine (NCoEDG) is a joint venture between the Joint Committee of the Nordic Medical Research Councils (NOS-M), the Nordic Council of Ministers and the Nordic Research Board (NordForsk).

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RNA-Seq transcriptomics and pathway analyses reveal potential regulatory genes and molecular mechanisms in high- and low-feed efficient Nordic dairy cattle

Project description:The study investigated gene expression patterns in liver tissue to understand the biological functions of genes that are potentially involved in controlling / regulating feed efficiency in Nordic dairy cattle.

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