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Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma.

ABSTRACT: Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma.

PROVIDER: PRJNA856162 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19996400.fastq.gz	Fastqsanger.gz
	SRR19996500.fastq.gz	Fastqsanger.gz
	SRR19996401.fastq.gz	Fastqsanger.gz
	SRR19996501.fastq.gz	Fastqsanger.gz
	SRR19996502.fastq.gz	Fastqsanger.gz

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Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [RNA-seq]

Project description:Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [RNA-seq]

| PRJNA856169 | ENA

Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ATAC-seq]

Project description:Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ATAC-seq]

| PRJNA856167 | ENA

Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ChIP-seq]

Project description:Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ChIP-seq]

| PRJNA856168 | ENA

Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ATAC-seq]

Project description:Transcriptional dysregulation of genes is a hallmark of tumors and can be pharmacologically developed in cancer. However, little is known about the interaction or transcriptional cooperativity between TF and transcription cofactor in gastroesophageal adenocarcinoma (GEA).

2024-06-05 | GSE207555 | GEO

Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ChIP-seq]

2024-06-05 | GSE207554 | GEO

Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [RNA-seq]

2024-06-05 | GSE207553 | GEO

Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma.

Project description: Not available

| S-EPMC11120281 | biostudies-literature

Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-05 | GSE207556 | GEO

The LIM protein Ajuba promotes a metastatic phenotype in colon cancer cells

Project description:RNA-seq of Colon cancer cell line Sw480 with Ajuba OE and KD.Colon cancer, along with its potential for recurrence and metastasis is a major health problem. Understanding the proteins and pathways that regulate cell growth and metastasis may provide new targets for patient care. Ajuba is a LIM domain protein often found overexpressed in cancers, however the exact function role of Ajuba in colon cancer is not known. Our data demonstrates that Ajuba is highly expressed in colon cancer cell lines and tumour tissue compared to adjacent non-tumour tissue. Using publicly available data from The Cancer Genome Atlas, we correlated poor colon cancer patient survival with high Ajuba expression. To investigate the function of Ajuba in colon cancer metastasis we transduced cells with lentiviral constructs to knock down and overexpress Ajuba protein and performed an RNA-seq transcriptomic analysis on each modified line. Analysing the pathways enriched in the differentially expressed genes, we found Ajuba to be involved in cell proliferation, migration and differentiation. We confirmed our findings in biological assays, cells depleted of Ajuba were less proliferative, more sensitive to irradiation, migrated less and were less efficient in colony formation. Our data indicates that increased Ajuba expression observed in colon cancer supports proliferation, epithelial-to-mesenchymal transition and metastasis.

2020-07-25 | GSE147111 | GEO

The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network

Project description:Background and Aims: The LIM protein AJUBA participates in the regulation of cell adhesion, mitosis, DNA damage, cell differentiation, proliferation, migration and gene transcription, yet its roles in tumor development and progression are poorly defined. The aim is to determine the role of AJUBA in colorectal tumorigenesis. Methods: We performed data mining in Oncomine databases and immunohistochemistry (IHC) assays on 67 paired colorectal cancer (CRC) samples; we manipulated the AJUBA expression in SW-1116 and Caco-2 cells using specific shRNA and overexpression plasmids and performed assays for cell viability, cell cycle and apoptosis; we performed RNA-seq and qRT-PCR assays to identify genes regulated by AJUBA; we performed western blot, co-immunoprecipitation assays to study the interaction of AJUBA and JAK/STAT; Results: We discovered that AJUBA is highly expressed in CRC and promotes CRC cell growth in culture and in xenograted mice via an inhibition of apoptosis by repression of the IFIT2 gene. AJUBA specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFNγ recepter, resulted in inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC specimens is negatively correlated with the levels of IFIT2 and pSTAT1. Conclusion: Ajuba functions as a specific suppressor of the Interferon-activated JAK1/STAT1 signaling to promote colorectal cancer development via an inhibition of Interferon induced apoptosis.

2017-02-23 | GSE84902 | GEO

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