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Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells mediates joint pathology during chikungunya

ABSTRACT: Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells mediates joint pathology during chikungunya

PROVIDER: PRJNA860070 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20307490_1.fastq.gz	Fastqsanger.gz
	SRR20307490_2.fastq.gz	Fastqsanger.gz
	SRR20307491_1.fastq.gz	Fastqsanger.gz
	SRR20307491_2.fastq.gz	Fastqsanger.gz
	SRR20307492_1.fastq.gz	Fastqsanger.gz

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Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells mediates joint pathology during chikungunya

Project description:Communications between immune cells are essential to ensure appropriate coordination of their activities. Here, we observed the infiltration of activated macrophages into the joint-footpads of chikungunya virus (CHIKV)-infected animals. Large numbers of CD64+MHCII+ and CD64+MHCII- macrophages were present in the joint-footpad, preceded by the recruitment of their CD11b+Ly6C+ inflammatory monocyte precursors. Regulation of these myeloid subsets was highly dependent on IFNγ and GM-CSF secreted by CHIKV-specific CD4+ T cells. Transcriptomic and gene ontology analyses of CD64+MHCII+ and CD64+MHCII- macrophages revealed 89 differentially expressed genes, including genes involved in T cell proliferation and differentiation pathways. Depletion of CD64+MHCII+ macrophages from CHIKV-infected mice reduced disease pathology, demonstrating that these cells play a pro-inflammatory role in CHIKV infection. Together, these results highlight the synergistic dynamics of immune cell crosstalk in driving CHIKV immunopathogenesis. This study provides new insights in the disease mechanism and offers opportunities for development of novel anti-CHIKV therapeutics.

2024-01-12 | GSE208540 | GEO

Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya

Project description: Not available

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Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya.

Project description: Not available

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Chikungunya virus persists in joint associated macrophages and promotes chronic disease [Xenium]

Project description:Arthritogenic alphaviruses, including chikungunya virus (CHIKV), Mayaro virus and Ross River virus, cause long-lasting musculoskeletal pain and inflammation. However, the mechanisms driving chronic disease remain unclear. Here, we used single-cell RNA sequencing, spatial transcriptomics and flow cytometry to investigate joint-associated tissues in alphavirus-infected mice at a late stage of infection. We identified an accumulation of inflammatory macrophages in joint-associated tissues with elevated expression of inflammatory markers. These cells harbour CHIKV RNA, suggesting ongoing viral replication during chronic disease. We also identified an accumulation of CD4+ T cells in these tissues expressing Ifng, and found that depletion of CD4+ T cells diminished major histocompatibility complex class II expression on joint macrophages, highlighting their potential role in inflammation. Treatment with a small molecule inhibitor of CHIKV replication during chronic disease reduced viral RNA and joint inflammation. Our data suggest that macrophages harbour replicating viral RNA and contribute to the sustained joint inflammation associated with chronic alphavirus disease.

2026-02-05 | GSE300303 | GEO

Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice [scRNA-seq]

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Chikungunya virus persists in joint associated macrophages and promotes chronic disease.[Xenium]

Project description:Chikungunya virus persists in joint associated macrophages and promotes chronic disease.[Xenium]

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Project description:Chikungunya virus persists in joint-associated macrophages and promotes chronic disease.

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Chikungunya virus persists in joint associated macrophages and promotes chronic disease.[scRNA-seq]

Project description:Chikungunya virus persists in joint associated macrophages and promotes chronic disease.[scRNA-seq]

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Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of middle-aged mice

Project description:Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of 12 months old (12 mo) mice. Results provide insight into the role of MHCII in HSC.

2023-08-08 | GSE211206 | GEO

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice under homeostasis

Project description:Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of 5 months old WT mice (Ctrl). Results provide insight into the role of MHCII in HSC.

2023-08-08 | GSE211203 | GEO

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