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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-seq tissue DC)

ABSTRACT: Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-seq tissue DC)

PROVIDER: PRJNA865709 | ENA |

REPOSITORIES: ENA

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

2023-12-31 | GSE183388 | GEO

Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq DC)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

Project description:Gut-draining mesenteric and celiac lymph nodes (mLNs and celLNs) critically contribute to peripheral tolerance towards food and microbial antigens by efficiently supporting the de novo induction of regulatory T cells (Tregs). These tolerogenic properties of mLNs and celLNs are stably imprinted within stromal cells (SCs) by microbial signals and vitamin A (VA), respectively. In the present study, we demonstrated that a transient neonatal gastrointestinal infection long-lastingly affects the functionality of celLN by permanently abrogating the efficient Treg-inducing capacity of celLN SCs. The neonatal infections durably shifted the heterogeneity of celLN SCs with permanently altered expression of genes involved in chemotaxis and inflammatory responses, resulting in a lastingly skewed dendritic cell (DC) composition. Mechanistically, transiently reduced VA levels caused the long-lastingly impaired celLN function, which could be rescued by an early-life VA supplementation. Together, our data highlight the therapeutic potential of VA treatment post gastrointestinal infections in infants.

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (scRNA-Seq)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

Project description:Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-Seq FSC)

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Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function (RNA-seq tissue DC)

Project description:To investigate whether transient neonatal infections long-lastingly alter the transcriptome of tissue dendritic cells, we isolated dendritic cells from the pancreas, the proximal duodenum, and the liver. We then performed gene expression profiling analysis using data obtained from low-input RNA-seq of these tissue-isolated dendritic cells.

2025-07-20 | GSE210420 | GEO

Vitamin A treatment rescues neonatal infection-induced durably impaired lymph node function

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-31 | GSE183391 | GEO

Defining DC response to cognate T cell interaction in the antigen-challenged lymph node [dataset 3]

Project description:We designed an experimental set up to probe DC responses to cognate T cell encounter in antigen draining LN

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