Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq and snRNA-seq analysis of Sleep deprivation in Wildtype Mice

ABSTRACT: RNA-Seq and snRNA-seq analysis of Sleep deprivation in Wildtype Mice

PROVIDER: PRJNA868792 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21020314.fastq.gz	Fastqsanger.gz
	SRR21020315.fastq.gz	Fastqsanger.gz
	SRR21020316.fastq.gz	Fastqsanger.gz
	SRR21020317.fastq.gz	Fastqsanger.gz
	SRR21020318.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 44

Similar Datasets

RNA-Seq and snRNA-seq analysis of Sleep deprivation in Wildtype Mice

Project description:This dataset constitutes the first snRNA-Seq study of gene expression following sleep deprivation in wildtype mice with paralell bulk-RNA-seq data. In addition it contains RNA-seq analysis of the effect of recovery sleep following sleep deprivation

2023-04-17 | GSE211088 | GEO

RNA-Seq analysis of Sleep deprivation in wildtype and Shank3 mutant mice

Project description:This dataset constitutes the first RNA-Seq study of gene expression following sleep deprivation in wildtype and Shank3 exon 21 mutant mice

2018-12-31 | GSE113754 | GEO

Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the murine cortex

Project description:Sleep loss regulates gene expression throughout the brain and impacts learning and memory. However, the molecular consequences of sleep deprivation and the ability of subsequent sleep (recovery sleep) to restore baseline gene expression remain underexplored. Our goal here is to overview transcriptional changes at the gene level in the cortex of adult male wildtype mice in response to sleep loss and recovery sleep. This dataset constitutes an integration of novel data with two publicly available RNA-seq studies and contains 3, 5, and 6 hours of sleep deprivation and 2 and 6 hours of recovery sleep time points.

2024-08-19 | GSE237419 | GEO

RNA-Seq analysis of Sleep deprivation in wildtype and Shank3 mutant mice

Project description:RNA-Seq analysis of Sleep deprivation in wildtype and Shank3 mutant mice

| PRJNA453921 | ENA

Microglia protect memories formed during sleep deprivation

Project description:Purpose: To determine the specific effects of 6 hours sleep deprivation after a learning event on the transcriptomes of microglia. Sleep deprivation can generate inflammatory responses in the neuronal environment. In turn, this inflammation increases sleep drive, leading to a rebound in sleep duration. Microglia, a type of support cell found exclusively in the brain, have previously been found to release of inflammatory signals and exhibit altered characteristics in response to sleep deprivation. Together, this suggests microglia may be partially responsible for the brain’s response to sleep deprivation through their inflammatory activity. In this study, we fully and selectively ablated microglia from the mouse brain and assessed resulting sleep, circadian, and sleep deprivation phenotypes. We find microglia are dispensable for both homeostatic sleep and circadian function and the sleep rebound response to sleep deprivation. However, we uncover a phenomenon by which microglia appear to be essential for the protection of synapses and associated memories formed during a period of sleep deprivation, further expanding the list of known functions for microglia in synaptic modulation.

2021-05-12 | GSE174231 | GEO

Altered hippocampal transcriptome dynamics following sleep deprivation

Project description:Purpose: To comprehensively identify the gene expression changes that occur after acute sleep deprivation. Method: We performed total RNA sequencing after 5hours of sleep deprivation. Results: Using total RNA-sequencing, we show that acute sleep deprivation causes dramatic gene expression changes in the mouse hippocampus. Conclusion: This study provides insight into the biological impact of acute sleep deprivation.

2021-03-01 | GSE166831 | GEO

Single-nucleus RNA-seq identifies one galanin neuronal subtype in mouse preoptic hypothalamus activated during recovery sleep after sleep deprivation

Project description:The preoptic area of hypothalamus plays an important role in sleep homeostasis. We used snRNA-seq to identify neurons involved in homeostatic sleep response.

2024-04-01 | GSE243489 | GEO

Sleep Deprivation and Recovery Sleep for 7 Regions of Mouse Brain.

Project description:Analysis of the effects of sleep deprivation, recovery sleep, and three time-of-day controls on seven brain regions laser microdissected from mouse brain. The regions include the locus coeruleus, suprachiasmatic nucleus, hypocretin area, tuberomammillary nucleus, orbital cortex, posteromedial cortical amygdala, and entorhinal cortex. In this study, 7 brain regions were collected by laser microdissection from brain tissue of mice from 5 different treatment groups and used for microarray experiments. Four biological replicates were generated for each regionxcondition. Conditions are: SD, sleep deprivation for 6 hours from ZT0 - 6; SDC, time-of-day control for SD at ZT6; RS, recovery sleep for 4 hours following SD; RSC, time-of-day control for RS at ZT10; W, spontaneous waking at ZT18.

2010-08-16 | E-GEOD-23628 | biostudies-arrayexpress

Prolonged sleep deprivation induces cytokine storm-like syndrome in mammals [scRNA-Seq]

Project description:Sleep is deeply involved in neuroimmune regulation, while the mechanism is yet to be elucidated. Experimental manipulation of sleep duration provides a reliable measure for evaluating how sleep regulates innate immunity. Here we report a modified sleep deprivation paradigm (SD) that can constantly awaken the mice with more than 95% efficiency, and investigate the effects of prolonged sleep deprivation on mice's immune systems.

2023-11-27 | GSE213496 | GEO

Prolonged sleep deprivation induces cytokine storm-like syndrome in mammals [RNA-Seq]

2023-11-27 | GSE213494 | GEO