Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [2]

ABSTRACT: Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [2]

PROVIDER: PRJNA869563 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR21048700.fastq.gz	Fastqsanger.gz
	SRR21048701.fastq.gz	Fastqsanger.gz
	SRR21048702.fastq.gz	Fastqsanger.gz
	SRR21048703.fastq.gz	Fastqsanger.gz
	SRR21048704.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [2]

Project description:Loss of SAMHD1 causes chronic activaiton of the MDA5/MAVS dsRNA sensing pathway, only when cGAS/STING signaling is intact.

2022-08-18 | GSE211209 | GEO

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [1]

Project description:Loss of SAMHD1 causes chronic activaiton of the MDA5/MAVS dsRNA sensing pathway, only when cGAS/STING signaling is intact.

2022-08-18 | GSE211208 | GEO

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner II

Project description:Loss of SAMHD1 causes chronic activaiton of the MDA5/MAVS dsRNA sensing pathway, only when cGAS/STING signaling is intact. Peritoneal macrophages from mutant and control mice were isolated by FACS. Total RNA was subjected to next generation mRNA sequencing.

2022-10-10 | GSE214712 | GEO

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner I

2022-10-10 | GSE214711 | GEO

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Project description:Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

| PRJNA869555 | ENA

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [1]

Project description:Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [1]

| PRJNA869560 | ENA

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner I

Project description:Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner I

| PRJNA886728 | ENA

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner II

Project description:Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner II

| PRJNA886727 | ENA

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner (Set II)

Project description:Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner (Set II)

| PRJNA886723 | ENA

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.

Project description:Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I interferon-driven inflammatory diseases. In these pathophysiological conditions, activation of the DNA sensor cGAS and IFN production are linked to spontaneous DNA damage. Physiological, or tonic, IFN signaling on the other hand is essential to functionally prime nucleic acid sensing pathways. Here, we show that low-level chronic DNA damage in mice lacking the Aicardi-Goutières syndrome gene SAMHD1 reduced tumor-free survival when crossed to a p53-deficient, but not to a DNA mismatch repair-deficient background. Increased DNA damage did not result in higher levels of type I interferon. Instead, we found that the chronic interferon response in SAMHD1-deficient mice was driven by the MDA5/MAVS pathway but required functional priming through the cGAS/STING pathway. Our work positions cGAS/STING upstream of tonic IFN signaling in Samhd1-deficient mice and highlights an important role of the pathway in physiological and pathophysiological innate immune priming.

| S-EPMC9648672 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data