Project description:Campylobacter hepaticus, the causative agent of spotty liver disease (SLD) in commercial layer hens, leads to liver necrosis, reduced egg production, and increased mortality. Despite its impact, the pathogen’s virulence mechanisms remain poorly understood. This study used high-throughput transcriptomics to analyze gene expression profiles of C. hepaticus cultured in vitro bile, infected with LMH cells, and SLD affected chicken livers (in vivo) obtained from field cases to uncover key factors involved in host adaptation and pathogenicity
Project description:Spotty Liver Disease (SLD) is an acute bacterial infection of layer hens, caused by Campylobacter hepaticus, and occurs most frequently in barn-housed and free-range production systems. The disease is characterized by a sharp decline in egg production and increased mortality.The characteristic feature is the presence of 1-2 mm white to grey necrotic foci distributed across the liver surface.Despise its impact,the molecular mechanisms underlying host responses to C. hepaticus infection remain poorly understood.To address this gap, we performed a comprehensive analysis using RNA sequencing of liver tissue from naturally infected chickens compared to uninfected controls.
Project description:Campylobacter jejuni has become the predominant cause of sheep abortions in the U.S. However, little is know about the genetic diversity among the isolates collected from different time periods. In this study, the genetic diversity of sheep aborion isolates of C. jejuni was investigated by Array-based CGH
Project description:Campylobacter jejuni has become the predominant cause of sheep abortions in the U.S. However, little is know about the genetic diversity among the isolates collected from different time periods. In this study, the genetic diversity of sheep abortion isolates of C. jejuni was investigated by Array-based CGH
2014-02-11 | GSE54858 | GEO
Project description:Campylobacter hepaticus from Georgia, USA
