Project description:Campylobacter hepaticus, the causative agent of spotty liver disease (SLD) in commercial layer hens, leads to liver necrosis, reduced egg production, and increased mortality. Despite its impact, the pathogen’s virulence mechanisms remain poorly understood. This study used high-throughput transcriptomics to analyze gene expression profiles of C. hepaticus cultured in vitro bile, infected with LMH cells, and SLD affected chicken livers (in vivo) obtained from field cases to uncover key factors involved in host adaptation and pathogenicity
Project description:We are investigating the transcriptional response of mice infected with Helicobacter hepaticus and links to liver cancer We used microarrays to detail the global programme of gene expression underlying H. hepaticus induced liver cancer Keywords: disease model