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DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance [ChIRP-seq]

ABSTRACT: DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance [ChIRP-seq]

PROVIDER: PRJNA881456 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21614748_1.fastq.gz	Fastqsanger.gz
	SRR21614748_2.fastq.gz	Fastqsanger.gz
	SRR21614749_1.fastq.gz	Fastqsanger.gz
	SRR21614749_2.fastq.gz	Fastqsanger.gz
	SRR21614750_1.fastq.gz	Fastqsanger.gz

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DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance [ChIRP-seq]

Project description:We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseudogene 1) in gastric carcinogenesis. We demonstrated that gastric cancer (GC) patients with high DUSP5P1 expression had shortened survival in two independent cohorts. DUSP5P1 promoted GC cell migration and invasion in vitro and metastasis in vivo. Mechanistically, DUSP5P1 activated ARHGAP5 transcription by directly binding to the promoter of ARHGAP5 with a binding motif of TATGTG. RNA-seq revealed that ARHGAP5 activated focal adhesion and MAPK signalling pathways to promote GC metastasis. DUSP5P1 also dysregulated platinum drug resistance pathway. Consistently, DUSP5P1 overexpression in GC cells antagonized cytotoxic effect of Oxaliplatin, and shDUSP5P1 plus Oxaliplatin exerted synergistic effect on inhibiting GC metastasis in vitro and in vivo. DUSP5P1 depletion also suppressed the growth of platinum drug-resistant PDO models. In conclusion, DUSP5P1 promoted GC metastasis by directly modulating ARHGAP5 expression to activate focal adhesion and MAPK pathways, serves as therapeutic target for platinum drug resistant GC, and is an independent prognostic factor in GC.

2022-11-18 | GSE213581 | GEO

DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance [RNA-seq]

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DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance

Project description:DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance

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DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance [RNA-seq]

Project description:DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance [RNA-seq]

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Gastric cancer genetic analysis of metastasis

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DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-11-18 | GSE213582 | GEO

DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance.

Project description:We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseudogene 1) in gastric carcinogenesis. We demonstrated that gastric cancer (GC) patients with high DUSP5P1 expression had shortened survival in two independent cohorts. DUSP5P1 promoted GC cell migration and invasion in vitro and metastasis in vivo. Mechanistically, DUSP5P1 activated ARHGAP5 transcription by directly binding to the promoter of ARHGAP5 with a binding motif of TATGTG. RNA-seq revealed that ARHGAP5 activated focal adhesion and MAPK signaling pathways to promote GC metastasis. DUSP5P1 also dysregulated platinum drug resistance pathway. Consistently, DUSP5P1 overexpression in GC cells antagonized cytotoxic effect of Oxaliplatin, and shDUSP5P1 plus Oxaliplatin exerted synergistic effect on inhibiting GC metastasis in vitro and in vivo. DUSP5P1 depletion also suppressed the growth of platinum drug-resistant PDO models. In conclusion, DUSP5P1 promoted GC metastasis by directly modulating ARHGAP5 expression to activate focal adhesion and MAPK pathways, serves as therapeutic target for platinum drug resistant GC, and is an independent prognostic factor in GC.

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Project description:<p>To identify candidate drivers involved in oncogenesis and tumor evolution, we conducted an extensive genome sequencing analysis of metastatic progression in diffuse gastric cancer. This involved a comparison between a primary tumor from a Hereditary Diffuse Gastric Cancer Syndrome proband and its subsequent recurrence as an ovarian metastasis.</p>

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