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Single cell RNA sequencing of SMC specific Yap1 knockout mouse aorta

ABSTRACT: single cell RNA sequencing of SMC specific Yap1 knockout mouse aorta

PROVIDER: PRJNA882183 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21634600_1.fastq.gz	Fastqsanger.gz
	SRR21634600_2.fastq.gz	Fastqsanger.gz
	SRR21634601_1.fastq.gz	Fastqsanger.gz
	SRR21634601_2.fastq.gz	Fastqsanger.gz
	SRR21634602_1.fastq.gz	Fastqsanger.gz

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single cell RNA sequencing of SMC specific Yap1 knockout mouse aorta

Project description:When aortic cells are under stress, such as increased hemodynamic pressure, they adapt to the environment by modifying their functions, allowing the aorta to maintain its strength. To understand the regulation of this adaptive response, we examined the transcriptomic and epigenomic programs in aortic smooth muscle cells (SMCs) during the adaptive response to angiotensin II (AngII) infusion and determined its importance in protecting against aortic aneurysm and dissection.

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