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Identification of direct connections between the dura and the brain [young + aged]

ABSTRACT: Identification of direct connections between the dura and the brain [young + aged]

PROVIDER: PRJNA882863 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21665097_1.fastq.gz	Fastqsanger.gz
	SRR21665097_2.fastq.gz	Fastqsanger.gz
	SRR21665098_1.fastq.gz	Fastqsanger.gz
	SRR21665098_2.fastq.gz	Fastqsanger.gz
	SRR21665099_1.fastq.gz	Fastqsanger.gz

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Identification of direct connections between the dura and the brain [young + aged]

Project description:The arachnoid barrier delineates the border between the central nervous system and dura mater. Although the arachnoid barrier creates a partition, communication between the central nervous system and the dura mater is crucial for waste clearance and immune surveillance. How the arachnoid barrier balances separation and communication is poorly understood. Leveraging transcriptomic data, we developed novel transgenic mice to examine specific anatomical structures that serve as routes across the arachnoid barrier. Bridging veins create discontinuities where they cross the arachnoid barrier, forming structures that we termed arachnoid cuff exit (ACE) points. The openings that ACE points create allow the exchange of fluids and molecules between the subarachnoid space and the dura, enabling the drainage of cerebrospinal fluid and limited entry of molecules from the dura to the subarachnoid space. In healthy human volunteers, MRI tracers transit along bridging veins in a similar fashion to access the subarachnoid space. Interestingly, in neuroinflammatory conditions such as experimental autoimmune encephalomyelitis, ACE points also allow cellular trafficking, representing a previously unknown route for immune cells to directly enter the subarachnoid space from the dura mater. Collectively, our results indicate that ACE points are a critical part of the anatomy of neuroimmune communication in both mice and humans that links the central nervous system with the dura and its immunological diversity and waste clearance systems.

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