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Cholangiocarcinoma cell line (CCA cell line KKU-213A) treated in lactic acidosis condition

ABSTRACT: Cholangiocarcinoma cell line (CCA cell line KKU-213A) treated in lactic acidosis condition

PROVIDER: PRJNA888376 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21845349.fastq.gz	Fastqsanger.gz
	SRR21845350.fastq.gz	Fastqsanger.gz
	SRR21845351.fastq.gz	Fastqsanger.gz
	SRR21845352.fastq.gz	Fastqsanger.gz
	SRR21845353.fastq.gz	Fastqsanger.gz

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Cholangiocarcinoma cell line (CCA cell line KKU-213A) treated in lactic acidosis condition

Project description:To understand the effect of lactic acidosis in cholangiocarcinoma cell line. Cells were cultured in different conditions: lactic acidosis, lactosis, acidosis and control. We found that lactic acidosis promoted aggressiveness of cancer cells and reprograming of metabolic.

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Serum exosome miRNA expression profile in patients with cholangiocarcinoma(CCA) and common bile duct stones(CBDS)

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FOSL1 target genes in cholangiocarcinoma (CCA) cells

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Lactic acidosis triggers starvation response with distinct metabolic profiles

Project description:[1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for different length of time. We used microarrays to examine the genomic programs of cells incubated under lactic acidosis for different length of time [2] Metabolic profiling: MCF7 cells were exposed to control condition, 25mM lactic acidosis, glucose deprivation (zero glucose) and hypoxia (1% oxygen level). [3] Mouse study: Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. Wild-type mouse embryo fibroblasts (MEFs) and TXNIP-null MEFs were exposed to Ctrl versus lactic acidosis conditions for 24hrs and the RNAs from cells were extracted with MiRVana kit (Ambion) and applied to Affymetrix 430A mouse chips We used microarrays to examine the genomic programs of cells incubated under different microenvironmental stresses. [1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for 1, 4, 12 and 24 hours. [2] Metabolic profiling: MCF7 cells were exposed to lactic acidosis, glucose deprivation and hypoxia for 4hours. [3] wild-type mouse embryo fibroblasts (MEFs) and TXNIP-null MEFs were exposed to Ctrl versus lactic acidosis conditions for 24hrs.

2010-09-27 | E-GEOD-19123 | biostudies-arrayexpress

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Project description:Human Mammalian Epithelial Cells (HMEC) were exposed to different environmental stresses, including hypoxia, lactic acidosis, the combination of hypoxia and lactic acidosis, lactosis , as well as acidosis. We used microarrays to examine the genomic programs of cells incubated under different microenvironments. Experiment Overall Design: HMEC cells were exposed to different environmental stresses and RNAs were extracted and put on Affymetrix microarrays. We gathered RNAs from cells grown in regular media (control), lactic acidosis, hypoxia, the combinatino of lactic acidosis and hypoxia, lactosis, as well as acidosis.

2009-01-13 | E-GEOD-9649 | biostudies-arrayexpress

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