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Epigenetic resetting in the human germline entails histone modification remodelling [RNA-Seq I]

ABSTRACT: Epigenetic resetting in the human germline entails histone modification remodelling [RNA-Seq I]

PROVIDER: PRJNA889527 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21866230_1.fastq.gz	Fastqsanger.gz
	SRR21866230_2.fastq.gz	Fastqsanger.gz
	SRR21866231_1.fastq.gz	Fastqsanger.gz
	SRR21866231_2.fastq.gz	Fastqsanger.gz
	SRR21866232_1.fastq.gz	Fastqsanger.gz

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Epigenetic resetting in the human germline entails histone modification remodelling

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Epigenetic resetting in the human germline entails histone modification remodelling [RNA-Seq II]

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Epigenetic resetting in the human germline entails histone modification remodelling [ChIP-Seq]

Project description:Epigenetic resetting in the mammalian germ line entailsacute DNA demethylation, which lays the foundation for gametogenesis, totipotency,and embryonic development. We characterize the epigenome of hypomethylated human primordial germ cells (hPGCs) to reveal mechanisms preventing the widespread derepression of genesand transposable elements (TEs). Along with the loss of DNA methylation, we show that hPGCsexhibit a profound reduction of repressive histone modifications resulting in diminished heterochromatic signaturesat most genesand TEsand the acquisition of a neutral or paused epigenetic state without transcriptional activation.Efficient maintenance of a heterochromatic state is limited to a subset of genomic loci, such asevolutionarily young TEsand some developmental genes, which require H3K9me3 and H3K27me3, respectively, forefficient transcriptional repression. Accordingly, transcriptional repression in hPGCs presentsan exemplary balanced system relying on local maintenance of heterochromatic featuresand a lack of inductive cues.

2023-01-18 | GSE215280 | GEO

Epigenetic resetting in the human germline entails histone modification remodelling [ATAC-Seq]

2023-01-18 | GSE215279 | GEO

Epigenetic resetting in the human germline entails histone modification remodelling [RNA-Seq II]

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Epigenetic resetting in the human germline entails histone modification remodelling [RNA-Seq I]

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Epigenetic resetting in the human germline entails histone modification remodelling

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-18 | GSE215283 | GEO

Epigenetic resetting in the human germ line entails histone modification remodeling.

Project description:Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic development. We characterize the epigenome of hypomethylated human primordial germ cells (hPGCs) to reveal mechanisms preventing the widespread derepression of genes and transposable elements (TEs). Along with the loss of DNA methylation, we show that hPGCs exhibit a profound reduction of repressive histone modifications resulting in diminished heterochromatic signatures at most genes and TEs and the acquisition of a neutral or paused epigenetic state without transcriptional activation. Efficient maintenance of a heterochromatic state is limited to a subset of genomic loci, such as evolutionarily young TEs and some developmental genes, which require H3K9me3 and H3K27me3, respectively, for efficient transcriptional repression. Accordingly, transcriptional repression in hPGCs presents an exemplary balanced system relying on local maintenance of heterochromatic features and a lack of inductive cues.

| S-EPMC9848478 | biostudies-literature

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