Project description:Our findings suggest that FtMt serves as a protective function in myocardial infarction by limiting infarct size, reducing the incidence of ventricular arrhythmias, and inhibiting ferroptosis both in vivo and in vitro. Our results also indicate that FtMt could be a promising therapeutic target for myocardial infarction.
Project description:To induce myocardial infarction, ligation of left anterior descending (LAD) coronary artery was performed for 5d. After 5d heart tisse was collected from the infarct zone of MI-mice and left ventricular tissue of sham operated mice.