Project description:To compare the H3K27ac effects of FK228 and Class I HDACs YF mutants overexpression and to characterize their inter-dependency, we performed ChIP-seq in AML12 cells in the above-mentioned 4 groups: control, FK228, YF overexpression, and FK228 + YF overexpression.
Project description:To compare the transcriptomic effects of FK228 and Class I HDACs YF mutants overexpression and to characterize their inter-dependency, we performed RNA-seq in AML12 cells in the above-mentioned 4 groups: control, FK228, YF overexpression, and FK228 + YF overexpression.
Project description:RNAseq was carried out to identify the transcriptomic changes that occur in healthy adult volunteers given either placebo or metformin from 3-days before to 3-days after live-attenuated YF-17D vaccination. Whole blood was collected at baseline (before placebo/metformin therapy), before YF-17D vaccination, Day 1, Day 3, Day 7 and Day 10 post YF-17D vaccination for RNAseq.
