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ABSTRACT: Gut Bacterium Bilophila wadsworthia impeded lifestyle intervention response in Gestational Diabetes Mellitus

PROVIDER: PRJNA898150 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22216041_1.fastq.gz	Fastqsanger.gz
	SRR22216041_2.fastq.gz	Fastqsanger.gz
	SRR22216042_1.fastq.gz	Fastqsanger.gz
	SRR22216042_2.fastq.gz	Fastqsanger.gz
	SRR22216043_1.fastq.gz	Fastqsanger.gz

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Project description:Bilophila wadsworthia inhibits the lifestyle intervention response in Gestational Diabetes Mellitus via L-glutamine regulation

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Project description:Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of the first taurine-respiring mouse gut bacterium. Taurinivorans muris represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. This dataset contains the total proteomic data from three independent growth conditions.

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Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [bacterial gene expression]

Project description:Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis remains unknown. Here, we showed that B. wadsworthia synergize with HFD to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis unraveled pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by B. wadsworthia. Pharmacological suppression of B. wadsworthia-associated inflammation unmasked the bacterium’s intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Finally, the probiotic Lactobacillus rhamnosus CNCM I-3690 was able to limit B. wadsworthia-induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results support a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.

2018-05-26 | GSE112387 | GEO

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [mouse gene expression]

2018-05-26 | GSE111451 | GEO

Project description:Bacterial microcompartments in Bilophila wadsworthia

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Project description:Circulating miRNAs for gestational diabetes mellitus

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Project description:DNA methylation and gestational diabetes mellitus

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Project description:The oligo microarray were used to determine gene expression profile of PBMC from gestational diabetes mellitus (GDM) patients.

2012-08-25 | E-MEXP-3349 | biostudies-arrayexpress

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