Project description:Carbapenem-resistant Klebsiella pneumoniae (CRKP), particularly the K64 serotype, poses a severe clinical threat due to its high virulence and multidrug resistance. In this study, we investigated the gene expression profiles of host lung tissues to understand the pathogenesis of K64-CRKP infection and the therapeutic mechanism of Dep44, a capsule-degrading depolymerase. An acute pneumonia mouse model was established via intranasal infection with K64-CRKP. We performed high-throughput RNA sequencing (RNA-seq) on lung tissues from four experimental groups: the negative control group (healthy mice), the positive control group (K64-CRKP infected model), the treatment group (infected mice treated with Dep44), and the drug control group (healthy mice treated with Dep44). The analysis aims to elucidate the host immune response to K64-CRKP infection and evaluate how Dep44 treatment modulates these transcriptomic changes to exert its therapeutic effect.
2025-12-02 | GSE311904 | GEO
Project description:draft genome sequence for the ST11 hvkp strains from China
| PRJNA391211 | ENA
Project description:Diversity of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in China
| PRJNA481412 | ENA
Project description:CRKP
| PRJNA778807 | ENA
Project description:CRKP
| PRJNA1207320 | ENA
Project description:CRKP
| PRJNA1209626 | ENA
Project description:WGS of 2024 CRKP in one hospital in Zhejiang, China
