Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Immunoediting instructs tumor metabolic reprogramming to support immune evasion [Bisulfite-seq]

ABSTRACT: Immunoediting instructs tumor metabolic reprogramming to support immune evasion [Bisulfite-seq]

PROVIDER: PRJNA899100 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22220989.fastq.gz	Fastqsanger.gz
	SRR22220990.fastq.gz	Fastqsanger.gz
	SRR22220991.fastq.gz	Fastqsanger.gz
	SRR22220992.fastq.gz	Fastqsanger.gz
	SRR22220993.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Immunoediting instructs tumor metabolic reprogramming to support immune evasion [Bisulfite-seq]

Project description:Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early staged tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by a non-canonical IFNg-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells for empowering them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.

2022-11-15 | GSE217481 | GEO

Immunoediting instructs tumor metabolic reprogramming to support immune evasion

Project description:Immunoediting instructs tumor metabolic reprogramming to support immune evasion

| PRJNA899086 | ENA