Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Distinct Fibroblast Progenitor Subpopulation Expedites Regenerative Mucosal Healing by Immunomodulation

ABSTRACT: Distinct Fibroblast Progenitor Subpopulation Expedites Regenerative Mucosal Healing by Immunomodulation

PROVIDER: PRJNA900216 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22254647_1.fastq.gz	Fastqsanger.gz
	SRR22254647_2.fastq.gz	Fastqsanger.gz
	SRR22254648_1.fastq.gz	Fastqsanger.gz
	SRR22254648_2.fastq.gz	Fastqsanger.gz
	SRR22254649_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 13

Similar Datasets

Distinct Fibroblast Progenitor Subpopulation Expedites Regenerative Mucosal Healing by Immunomodulation

Project description:Oral fibroblasts are speculated to exhibit superior healing capacity. We used scRNA-seq to investigate oral fibroblast heterogeneity in mouse and human palate tissues.

2022-12-19 | GSE217720 | GEO

Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation.

Project description: Not available

| S-EPMC9827523 | biostudies-literature

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

| PRJNA691670 | ENA

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

| PRJNA756289 | ENA

Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells

Project description:Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells

| PRJNA1449014 | ENA

A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

Project description:A Growth Factor-Expressing Macrophage subpopulation orchestrates regenerative inflammation via GDF-15

| PRJNA691672 | ENA

miR-Seq on paired skin and oral mucosal wound healing

Project description:miR-Seq on paired skin and oral mucosal wound healing

| PRJNA501906 | ENA

Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells [1]

Project description:Regeneration enables organisms to repair damaged tissues, yet this capacity is strikingly limited in the cochlear sensory epithelium, essential for sound detection. A major cause of hearing loss arises from the irreversible loss of sensory hair cells (HCs) in the cochlea. While supporting cells (SCs) have a latent ability to trans-differentiate into HCs, this regenerative potential is rapidly lost after development. Using live imaging and single-cell multiomics of cochlear explants, we uncovered the cellular and molecular heterogeneity underlying the limited regenerative capacity of the neonatal mouse cochlea. Notch repression broadly silenced key SC genes, yet only a rare subpopulation of Deiters cells (DC), termed responsive DCs, initiated the trans-differentiation into HC fate. These cells underwent coordinated transcriptional and enhancer remodeling, linking epigenetic priming with morphological plasticity, while other SCs remained refractory despite robust Notch targets downregulation. Our study provides a molecular definition of a fate-primed SC state, revealing Notch inhibition as a selective trigger that unmasks rare regenerative competence.

2026-04-30 | GSE310785 | GEO

Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells [2]

2026-04-01 | GSE313875 | GEO

Neotenic phenomenon in gene expression in the skin of Foxn1 deficient (nude) mice– projection for regenerative skin wound healing

Project description:Uninjured skin of adult C57BL/6J mice and mouse fetuses at 18 day of embryonic development (E18), as the models of reparative healing, and Nude and E14, as the models of regenerative healing, were characterized for their gene expression profiles by next-generation high-throughput DNA sequencing. The comparisons of gene expression profiles indicated that there were more similarities within each model of healing (Nude was more similar to E14 and B6 was more similar to E18). The analysis revealed that Nude and E14 showed in common the up-regulation of genes associated with tissue remodeling, cytoskeletal rearrangements, wound healing and immune response and the down-regulation of genes coupled to differentiation. Gene expression profiles of regenerative adult Nude mice display features of an attenuated skin development resembling that of E14 mice, thus the Nude mouse may be considered as a unique example of neoteny among mammals. The similar expression profiles of genes in the skin of both Nude and E14 mice are direct or indirect consequences of FOXN1 deficiency. FOXN1 appears to regulate the balance between cell proliferation and differentiation and its lack creates a pro-regenerative environment.

2016-12-30 | GSE71619 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data