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Hyphthalamic mRNA expression of leptin receptor-expressing cell-specific Slug knockout mice

ABSTRACT: Hyphthalamic mRNA expression of leptin receptor-expressing cell-specific Slug knockout mice

PROVIDER: PRJNA900258 | ENA |

REPOSITORIES: ENA

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Hyphthalamic mRNA expression of leptin receptor-expressing cell-specific Slug knockout mice

Project description:Leptin resistance is a driving force for obesity and metabolic syndrome. Slug (Snai2 or Snail2) is an epignetic factor that may play a critical role in the development of leptin resistance in obesity. We conducted a microarray to detect molecular targets of Slug in the hypothalamus.

2022-11-15 | GSE217748 | GEO

Slug-dependent UVR induction of cytokines and chemokines

Project description:Studies of the zinc finger transcription factors Slug and Snail have largely focused on their important role in modulating epithelial-mesenchymal transition during embryonic development and tumor progression. However, these transcription factors also appear to regulate local inflammation. In previous studies, we showed that Slug knockout mice were resistant to sunburn, an acute cutaneous inflammatory response, compared to wild type mice. In the present studies, we used Slug knockout, chimeric Slug knockout/wild type, conditional Slug knockout, and Slug transgenic mice to study the role of Slug in ultraviolet radiation (UVR)-induced cutaneous inflammation. We demonstrated, using immunohistochemistry, in vivo imaging, and neutrophil migration studies, that it was Slug expression in the epidermis rather than in neutrophils that modulated the UVR response. Microarray analysis indicated that this modulation was effected by the production of epidermal cytokines, including CCL3, CCL4, oncostatin, and interleukin-1β, that recruited neutrophils to UVR-exposed skin. The pattern of pro-inflammatory gene regulation by Slug suggested a central role for NF-κB in mediating gene induction. Immunohistochemical analysis of UVR-induced NF-κB activation demonstrated reduced activation in Slug knockout and enhanced activation in Slug transgenic epidermis. Slug thus appears to modulate NF-κB activation in response to UVR.

2016-08-27 | GSE86107 | GEO

Cardiac adventitial leptin receptor-expressing fibroblasts have a unique epigenetic landscape [mouse ATAC-Seq]

Project description:Cardiac adventitial leptin receptor-expressing fibroblasts have a unique epigenetic landscape [mouse ATAC-Seq]

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RNA-sequencing of preoptic area leptin receptor-expressing neurons from heat acclimated LepRCreHTB mice

Project description:RNA-sequencing of preoptic area leptin receptor-expressing neurons from heat acclimated LepRCreHTB mice

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Transciption profiling of leptin receptor-expressing neurons in the Nucleus of the Solitary Tract

Project description:Transciption profiling of leptin receptor-expressing neurons in the Nucleus of the Solitary Tract

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RNA-sequencing of preoptic area leptin receptor-expressing neurons from heat acclimated LepRCreHTB mice

Project description:This experiment intended to look for the transcriptome changes that happen in neuronal cells from the preoptic area of the hypothalamus expressing leptin receptors during heat acclimation conditions. 3 groups of animals were used; long-term heat-acclimated animals constantly exposed to 36˚C for 28-35 days, short-term heat-acclimated animals constantly exposed to 36˚C for 5 days, and non-habituated (non-acclimated) animals which were not exposed to heat. The animal line used was LepRCreHTB.

2024-05-06 | E-MTAB-14029 | biostudies-arrayexpress

Transciption profiling of leptin receptor-expressing neurons in the Nucleus of the Solitary Tract

Project description:This study aims to identify and compare unique transcription profiles of neurons in the NTS that express the leptin receptor. We conducted single-cell patch RNA-sequencing experiments to classify neurons first by their unique firing properties and, second, transciptional profiles. We found two unique cellular populations: type1 and type2 distinguishable by firing patterns and transciption profile.

2020-12-07 | GSE158582 | GEO

Single-cell profiling unravels bone marrow stromal remodeling driven by leptin receptor-expressing mesenchymal precursors in myelofibrosis

Project description:Single-cell profiling unravels bone marrow stromal remodeling driven by leptin receptor-expressing mesenchymal precursors in myelofibrosis

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Expression analysis of HepG2, HepG2-slug and HepG2-slug on Matrigel

Project description:Investigation of whole genome gene expression level changes in hepatocellular carcinoma cell line hepG2 in regular culture, hepG2-slug in regular culture and hepG2-slug on Matrigel. Whole genome gene expression level changes have been compared in hepatocellular carcinoma cell line hepG2 in regular culture, hepG2-slug in regular culture and hepG2-slug on Matrigel.

2012-09-21 | GSE41026 | GEO

Comparison of gene expression profiles of effector T cells from leptin-receptor-deficient mice and wild type mice

Project description:We have employed whole genome microarray expression profiling as a discovery platform to identify genes differentially expressed during leptin receptor deficiency, which is partly responsible for the inhibition of T cell effector functions. Mouse CD4+CD25- T cells were purified from leptin-receptor-deficient mice and wild type mice, and stimulated with anti-CD3 and anti-CD28 for 12h. Six mice of each genotype were used. Leptin receptor deficiency-induced gene expression profiles were evaluated in mouse effector T cells from db/db mice and compared to the ones observed in their WT counterpart (db/+ mice). Two independent experiments were performed, and in each of them, 3 mice/group were pooled.

2012-09-05 | E-GEOD-29607 | biostudies-arrayexpress

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