Escherichia coli
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA90353 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Raw data for spatial pattern analysis of gyrase binding in E. coli MG1655 wild type and gyrA D82G mutant (ChIP-chip data) Keywords: other
2004-09-09 | GSE1735 | GEO
Project description:Raw data for spatial pattern analysis of gyrase binding in E. coli MG1655 wild type and gyrA D82G mutant (ChIP-chip data)
2004-09-09 | E-GEOD-1735 | biostudies-arrayexpress
Project description:- mRNA abundance from wild type grown in LB or M9 (mRNA vs. Genomic DNA) : GSM30231 - GSM30238, GSM30338-GSM30341 - mRNA abundance grown in LB with norfloxacin treatment for 10 min or 30 min (mRNA vs. Genomic DNA): GSM30247-GSM30262 - mRNA abundance from gyrA (D82G) mutant grown in LB (mRNA vs. Genomic DNA):GSM30239-GSM30246 - Transcription profile between wild type and gyrA (D82G) mutant: GSM30330-GSM30337 Keywords: other
2004-09-09 | GSE1730 | GEO
Project description:We investigated the impact of cadmium on the global transcriptome of E. coli wild type, ∆gshA and ∆gshB mutant cells to evaluate the molecular basis of cadmium toxicity in the presence or absence of cellular thiols. This global transcriptome analysis were done with cells synthezising GSH (wild type), gamma-glutamyl-cysteine (∆gshB mutant) or neither of the two cellular thiols (∆gshA mutant) under the influence of 100 µM Cd(II).
2008-05-31 | GSE11562 | GEO
Project description:DNA damage induces the mutations that drive bacterial adaption, evolution, and antibiotic escape. Both mutagenic and non-mutagenic DNA damage repair is coordinated by the SOS response, but despite extensive work, the functions of some SOS-induced genes remain obscure. Here, we clarify the function of Escherichia coli SbmC (GyrI). Despite its proposed function as a gyrase inhibitor, cells either lacking or overexpressing SbmC instead exhibit phenotypes consistent with a role in limiting DNA damage and cellular variation. Importantly, SbmC levels inversely correlate with E. coli mutation rate. Excess SbmC limits mutation whereas loss of SbmC increases mutation, possibly because ∆sbmC cells variably induce the SOS response, including mutagenic DNA Pol V. We additionally show that SbmC is dispensable for survival in the presence of double-strand break inducing drugs but is required to limit their mutational effects. Finally, evolutionary analysis indicates that bacterial SbmC homologs maintain their small molecule-binding domain but not the gyrase interacting residues identified in E. coli. Together, our findings suggest that SbmC-like proteins may bind to a yet-unknown cofactor to limit DNA damage and organismal evolution.
2026-03-11 | GSE324174 | GEO
Project description:Wild type E.coli SE15 vs. LuxS mutant E.coli SE15
| PRJNA213987 | ENA
Project description:- mRNA abundance from wild type grown in LB or M9 (mRNA vs. Genomic DNA) : GSM30231 - GSM30238, GSM30338-GSM30341 - mRNA abundance grown in LB with norfloxacin treatment for 10 min or 30 min (mRNA vs. Genomic DNA): GSM30247-GSM30262 - mRNA abundance from gyrA (D82G) mutant grown in LB (mRNA vs. Genomic DNA):GSM30239-GSM30246 - Transcription profile between wild type and gyrA (D82G) mutant: GSM30330-GSM30337
2004-09-09 | E-GEOD-1730 | biostudies-arrayexpress
Project description:Expression data of the acrR mutant E.coli compared to wild-type
| PRJNA335361 | ENA
Project description:E. coli K-12 mutant yjgI biofilm vs. wild type biofilm
| PRJNA128971 | ENA
Project description:Escherichia coli K-12: luxS mutant LW12 vs. wild type W3110
| PRJNA124781 | ENA