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Characterization of mu opioid receptor cells in a new Oprm1-cre mouse

ABSTRACT: Characterization of mu opioid receptor cells in a new Oprm1-cre mouse

PROVIDER: PRJNA904324 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22381706_1.fastq.gz	Fastqsanger.gz
	SRR22381706_2.fastq.gz	Fastqsanger.gz
	SRR22381707_1.fastq.gz	Fastqsanger.gz
	SRR22381707_2.fastq.gz	Fastqsanger.gz
	SRR22381708_1.fastq.gz	Fastqsanger.gz

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Characterization of mu opioid receptor cells in a new Oprm1-cre mouse

Project description:we derived, validated, and applied a novel MOR-specific Cre mouse line, inserting a T2A cleavable peptide sequence and the Cre coding sequence into the MOR 3’UTR. Importantly, this line shows specificity and fidelity of MOR expression throughout the brain and with respect to function, there were no differences in behavioral responses to morphine when compared to wild type mice, nor are there any alterations in Oprm1 gene expression or receptor density. To assess Cre recombinase activity, MOR-Cre mice were crossed with the floxed GFP-reporters, RosaLSLSun1-sfGFP or RosaLSL-GFP-L10a. The latter allowed for cell type specific RNA sequencing via TRAP (Translating Ribosome Affinity Purification) of striatal MOR+ neurons following opioid withdrawal.

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Oprm1

Project description:Rattus norvegicus Oprm1, opioid receptor, mu 1 [Source:RGD Symbol;Acc:3234], is differentially expressed in 13 experiment(s);

| ENSRNOG00000018191 | ExpressionAtlas

Oprm1

Project description:Rattus norvegicus Oprm1, opioid receptor, mu 1 [Source:RGD Symbol;Acc:3234], is expressed in 3 baseline experiment(s);

| ENSRNOG00000018191 | ExpressionAtlas

OPRM1

Project description:Monodelphis domestica OPRM1, opioid receptor mu 1 [Source:NCBI gene;Acc:100032253], is expressed in 1 baseline experiment(s);

| ENSMODG00000008382 | ExpressionAtlas

OPRM1

Project description:Sus scrofa OPRM1, opioid receptor mu 1 [Source:VGNC Symbol;Acc:VGNC:91055], is expressed in 1 baseline experiment(s);

| ENSSSCG00000004074 | ExpressionAtlas

Oprm1

Project description:Mus musculus Oprm1, opioid receptor, mu 1 [Source:MGI Symbol;Acc:MGI:97441], is differentially expressed in 20 experiment(s);

| ENSMUSG00000000766 | ExpressionAtlas

OPRM1

Project description:Oryctolagus cuniculus OPRM1, opioid receptor mu 1 [Source:HGNC Symbol;Acc:HGNC:8156], is expressed in 1 baseline experiment(s);

| ENSOCUG00000016025 | ExpressionAtlas

OPRM1

Project description:Homo sapiens OPRM1, opioid receptor mu 1 [Source:HGNC Symbol;Acc:HGNC:8156], is expressed in 19 baseline experiment(s);

| ENSG00000112038 | ExpressionAtlas

OPRM1

Project description:Macaca mulatta OPRM1, opioid receptor mu 1 [Source:VGNC Symbol;Acc:VGNC:83440], is expressed in 2 baseline experiment(s);

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