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Chronic pulmonary bacterial infections facilitate breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils II

ABSTRACT: Chronic pulmonary bacterial infections facilitate breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils II

PROVIDER: PRJNA904755 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22395738_1.fastq.gz	Fastqsanger.gz
	SRR22395738_2.fastq.gz	Fastqsanger.gz
	SRR22395739_1.fastq.gz	Fastqsanger.gz
	SRR22395739_2.fastq.gz	Fastqsanger.gz
	SRR22395740_1.fastq.gz	Fastqsanger.gz

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Chronic pulmonary bacterial infections facilitate breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils

Project description:Chronic pulmonary bacterial infections facilitate breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils

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Chronic pulmonary bacterial infections facilitate breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils

Project description:To investigate whether MHCIIhi neutrophils have tumor-promoting properties, we performed RNA-sequencing (RNA-seq) on MHCIIhi neutrophils and MHCIIlow neutrophils isolated from the lung and peripheral blood of tumor-bearing mice.

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Chronic pulmonary bacterial infections facilitate breast cancer lung metastasis with tumor-promoting MHCIIhi neutrophils II

Project description:In order to explore whether the tumor-promoting phenotype of MHCIIhi neutrophils was directly affected by bacterial chronic infection, we isolated MHCIIhi neutrophils cells from the lungs of both of CI tumor-bearing mice and CTRL tumor-bearing mice.

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The Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Project description:<p>Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is not well understood, our study highlights a perspective in AnxA1 as a target protein in control the immune response during fungi infection. C57BL/6 wild-type (WT) and AnxA1 knockout (AnxA1-/-) peritoneal neutrophils were coinfected with Candida albicans or Candida auris for 4 hours. High levels of COX-2 were observed in WT and AnxA1-/- neutrophils infected with C. albicans and C. auris coinfection. In addition, AnxA1-/- neutrophils exhibited a marked increase of phosphorylated ERK, p-38 and JNK levels after coinfection with both Candida spp. Lipidomics approach shows that lack of AnxA1 produced a marked difference in lipid profile of control or coinfected neutrophil supernatants compared to WT, especially glycerophospholipids and glycerolipids. In summary, our results showed that endogenous AnxA1 regulates neutrophil response under fungal infection and its lipid membrane organization and metabolism.  </p>

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