Project description:This dataset contains raw ChIP-seq data from esophageal squamous cell carcinoma (ESCC) cells overexpressing TFAP2β or its LLPS-deficient mutants (ΔIDR3 or Mut_IDR3). The experiment aims to explore the chromatin binding profiles of TFAP2β and its phase separation-deficient mutants to uncover the role of TFAP2β's LLPS activity in regulating gene expression in ESCC. Data were collected from the genomic binding of TFAP2β and its LLPS-deficient mutants, providing insights into the regulatory networks controlled by TFAP2β in cancer progression.
Project description:To explore the role of smooth muscle cell (SMC) Ano1 in atherosclerosis, Ano1 SMC-sepcific knockout mice (Ano1<SMCKO>) and the control mice (WT<SMC>) were injected with AAV-PCSK9DY followed by feeding a high-fat diet for 12 weeks. Subsequently, mouse aortic SMCs (MASMCs) were isolated and subjected to Chip sequencing (ChIP-seq) analysis.
Project description:This dataset contains raw RNA-seq data from esophageal squamous cell carcinoma (ESCC) cells overexpressing GFP-TFAP2β, its LLPS-deficient mutants (ΔIDR3 and Mut_IDR3) or GFP control. The experiment aims to explore the downstream genes of TFAP2β and its phase separation-deficient mutants to uncover the role of TFAP2β's LLPS activity in regulating gene expression in ESCC. Data were collected from the genomic binding of TFAP2β and its LLPS-deficient mutants, providing insights into the regulatory networks controlled by TFAP2β in cancer progression.
Project description:The overall goal of this study was to compare gene expression profiles in MOAB-overexpressing PrSC cells and control cells, also to compare gene expression profiles in MAOB-knockdown and control cells.
