Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression in untreated and TGF-b2-treated human bone marrow-derived mesenchymal stem cells

ABSTRACT: Gene expression in untreated and TGF-b2-treated human bone marrow-derived mesenchymal stem cells

PROVIDER: PRJNA909591 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR22560354_1.fastq.gz	Fastqsanger.gz
	SRR22560354_2.fastq.gz	Fastqsanger.gz
	SRR22560355_1.fastq.gz	Fastqsanger.gz
	SRR22560355_2.fastq.gz	Fastqsanger.gz
	SRR22560356_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Gene expression in untreated and TGF-b2-treated human bone marrow-derived mesenchymal stem cells

Project description:To investigate the transcriptome level changes in human bone marrow-derived mesenchymal stem cells following treatment with TGF-b2, we used RNA-sequencing to compare gene expression between cells from the same donors cultured in standard media or media containing 1 ng/ml TGF-b2.

2023-01-30 | GSE220294 | GEO

Gene expression in untreated and TGF-b2-treated equine bone marrow-derived mesenchymal stem cells

Project description:To investigate the transcriptome level changes in gene expression in equine mesenchymal stem cells following treatment with TGF-b2, we used RNA-sequencing to compare gene expression between mesenchymal stem cells from the same donor horses cultured in standard media and media containing TGF-b2.

2022-07-06 | GSE207394 | GEO

Gene expression in untreated and TGF-b2-treated equine bone marrow-derived mesenchymal stem cells

Project description:Gene expression in untreated and TGF-b2-treated equine bone marrow-derived mesenchymal stem cells

| PRJNA855231 | ENA

TGF-β signaling plays an essential role in the lineage specification of mesenchymal stem/progenitor cells in fetal bone marrow

Project description:TGF-β regulates fetale bone marrow niche emergence. Abrogating TGF-β signaling in mesenchymal cells during development results in a marked expansion of adipocytes and CAR cells in the bone marrow, while osteoblasts are reduced. RNA expression data from Osx-Cre targeted mesenchymal stromal cells obtained from E16.5 mouse hindlimbs of transgenic mice lacking Tgfbr2 in mesenchymal stromal cells or littermate controls.

2019-05-15 | GSE131219 | GEO

Plexin-B2-bound proteins purified by immunoprecipitation using anti-Plexin-B2 antibody

Project description:To identify Plexin-B2-associated proteins, articular chondrocytes were untreated or treated with Sema4D. Plexin-B2-bound proteins were purified by immunoprecipitation using an anti-Plexin-B2 antibody, followed by mass spectrometry.

2022-11-01 | PXD034551 | JPOST Repository

Membrane-bound TGF-beta on tumor-associated mesenchymal stem-like cells initiates epithelial-to-mesenchymal transition in human colorectal cancer

Project description:Growing evidence indicates that tumor-associated stroma plays a negative role in human colorectal cancer (CRC). Nature of specific stromal cell populations involved and mechanisms underlying their negative impact remain to be fully understood. In this study we describe the expansion from human primary CRCs of a mesenchymal cell population, referred to as tumor-associated stromal cells (TASCs), resembling bone marrow-derived mesenchymal stem cells (BM-MSCs) in morphology, phenotypes and differentiation potential. We found that, upon co-culture with tumor cells, TASCs acquire membrane-bound TGF-mbTGF-expression, a phenomenon mediated by v6 integrin. MbTGF-expression proved to be critical for triggering epithelial-to-mesenchymal transition (EMT) in tumor cells, eventually leading to enhanced dissemination of circulating tumor cells and increased metastasis formation, in an orthotopic mouse model. Our data identify CRC-associated mesenchymal stem-like cells as critical EMT initiators and suggest mbTGF- as potential novel therapeutic target.

2022-05-19 | PXD005796 | Pride

Endothelial to Mesenchymal Transition

Project description:Driving HUVECs toward mesenchymal fate Comparison of untreated HUVECs, HUVECs treated with TGF-B, HUVECS treated with TGF-B and oxidative stress, and comparator human dermal fibroblasts

2016-04-05 | E-GEOD-56309 | biostudies-arrayexpress

TGF-b2 regulates Theileria annulata gene transcription

Project description:TGF-b2 drives catalase transcription to regulate tumor H2O2 levels, and Theileria gene expression in transformed macrophages

| PRJEB19381 | ENA

Effect of chronic lymphocytic leukemia-derived exosomes on human bone marrow mesenchymal stem cells

Project description:Transcription profiling of human bone marrow mesenchymal stem cells treated with exosomes isolated from chronic lymphocytic leukemia cell line MEC-1 supernatant. Cells were left untreated or treated with CLL-exosomes for 6h at 37C.

2015-06-21 | E-MTAB-2765 | biostudies-arrayexpress

TGF-β1 induces bone marrow NK cells dysfunction

Project description:TGF-β1 induces bone marrow NK cells dysfunction

| PRJNA787546 | ENA