Project description:Objective: Identify genes that are differentially expressed between critically ill trauma patients who go on to develop ventilator-associated pneumonia (VAP) compared to similar patients who do not develop VAP Using gene expression differences, develop a model that predicts which patients are at greater risk of developing VAP. Prospective observational study, analysis of gene expression in 20 patient samples, 10 that developed ventilator-associated pneumonia, 10 that did not
Project description:Clinical decision-making in patients with community-acquired pneumonia at risk of organ dysfunction and death is currently aided by clinical scores. Here, we compare transcriptomes of patients to identify a signature to better identifie patients-at-risk for ICU admission and death. For this, we analyse time-course transcriptomic data from samples of a prospective observational cohort study that included hospitalized CAP across 63 centers in Germany (‘PROGRESS’; clinicaltrials.gov NCT02782013). This case-control study consisted of discovery (n=240) and validation cohorts (n=215) where transcriptomic data were analyzed for association with a composite endpoint (cEP) of qualified ICU admission and 28-day mortality.
Project description:Using a metaproteome approach in addition to a standard plaque-regrowth study, this study examined the impact of different concentrations of lactoperoxidase (LPO) in two lozenge formulations on early plaque formation, microbiome composition, and active biological processes in young orally healthy volunteers.
Project description:We collected samples from the buccal mucosa of six patients with aspiration pneumonia (AP) and six control patients (no AP) in an acute-care hospital.
