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A4b7 engagement triggers CD4+ T cell differentiation into TRM cells that are susceptible to HIV infection

ABSTRACT: a4b7 engagement triggers CD4+ T cell differentiation into TRM cells that are susceptible to HIV infection

PROVIDER: PRJNA914297 | ENA |

REPOSITORIES: ENA

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a4b7 engagement triggers CD4+ T cell differentiation into TRM cells that are susceptible to HIV infection

Project description:We report that MAdCAM and retinoic acid (RA), two constituents of gut tissues, together with TGF-b, promote the differentiation of CD4+ T cells into a distinct subset a4b7+ CD69+ CD103+ TRMs. These findings provide a framework to better understand the contribution of CD4+ TRMs to persistent viral reservoirs and HIV pathogenesis.

2022-12-21 | GSE221434 | GEO

Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling

Project description:Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling

| PRJNA1210512 | ENA

Engagement of ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

Project description:Recirculating and tissue-resident memory CD8+ T cells provide distinct modes of immune protection, yet the signals that dictate differentiation of these populations are ill-defined. In particular, the interactions within tissues that promote generation of resident memory T cells (TRM) are unclear. Here, we show that the inducible costimulatory molecule ICOS, well known to regulate differentiation of CD4+ T cell populations, is required for CD8+ TRM but not recirculating memory subsets. Furthermore, ICOS engagement during CD8+ T cell recruitment to non-lymphoid tissues is critical for efficient TRM establishment: ICOS/ICOS-L interactions are dispensable throughout CD8+ T cell priming and for TRM maintenance, while ICOS-L expression by radioresistant cells is key for optimal TRM generation. This role for ICOS depends on its ability to signal through PI3K. Together, our data illustrate that specific local costimulatory cues promote production of tissue-resident populations, with potential implication for therapeutic manipulation.

2021-12-20 | GSE185342 | GEO

Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling [RNA-Seq]

Project description:Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling [RNA-Seq]

| PRJNA1209965 | ENA

Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling [scRNA-Seq]

Project description:Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling [scRNA-Seq]

| PRJNA1210519 | ENA

HIV specific CD8+ Trm-like cells in tonsils express exhaustive signatures in the absence of natural HIV control [Seqwell]

Project description:Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great interest, but limited data exist on TRM-like cells within lymph nodes of people living with HIV (PLWH). Here, we studied tonsil CD8+ T-cells obtained from PLWH and uninfected controls from South Africa. We show that these cells are preferentially located outside the germinal centers (GCs), the main reservoir site for HIV, and display a low cytolytic and transcriptionally TRMlike profile distinct from blood CD8+ T-cells. In PLWH, CD8+ TRM-like cells are highly expanded and adopt a more cytolytic, activated, and exhausted phenotype not reversed by antiretroviral therapy (ART). This phenotype was enhanced in HIV-specific CD8+ T-cells from tonsils compared to matched blood suggesting a higher antigen burden in tonsils. Single-cell transcriptional and clonotype resolution showed that these HIV-specific CD8+ T-cells in the tonsils express heterogeneous signatures of T-cell activation, clonal expansion, and exhaustion ex-vivo. Interestingly, this signature was absent in a natural HIV controller, who expressed lower PD-1 and CXCR5 levels and reduced transcriptional evidence of T-cell activation, exhaustion, and cytolytic activity. These data provide important insights into lymphoid tissue-derived HIVspecific CD8+ TRM-like phenotypes in settings of HIV remission and highlight their potential for immunotherapy and targeting of the HIV reservoirs.

2022-10-12 | GSE215125 | GEO

HIV specific CD8+ Trm-like cells in tonsils express exhaustive signatures in the absence of natural HIV control [smart-seq 2]

2022-10-12 | GSE215126 | GEO

Side population phenotype in quiescent human/murine tissue resident memory (TRM) T cells: Role of ABC transporters and NR4A1 in TRM biology

Project description:The ability to detect and isolate human CD8 TSP (Side population), NaÃ¯ve, Effector memory (EM), Central memory (CM) cells allowed us to compare the global gene expression profiles of these cells. Human TSP cells comprise of distinct gene expression profile specifically enriched for genes overexpressed in TRM cells. RNA samples from CD8 TSP (Side population), NaÃ¯ve, Effector memory (EM), Central memory (CM) cells were amplified, labeled, and hybridized on the Affymetrix Human Genome U133 Plus 2.0 microarray chips. The data were analyzed with GeneSpring GX 12.5 (Agilent Technologies)

2016-08-02 | E-GEOD-85074 | biostudies-arrayexpress

Comparison of sorted TRM populations and TRM-like cells in vitro

Project description:Comparison of sorted TRM populations and TRM-like cells in vitro

| PRJNA804542 | ENA

Single cell CITE-seq and VDJ sequencing of CD8+ central memory blood T cells (TCM) and their in-vivo matured tissue-resident memory-like T cells (TRM)

Project description:The aim of the experiment was to understand the clonal relationship between CD8+ central memory blood T cells (TCM) and the in-vivo matured TCM tissue-resident memory-like T cells (TRM) on day 14. TCM were FACS sorted from human PBMCs (n=5). Half of the cells were processed on day 1 and half of the cells of each donor were matured into TRM with anti-CD3, IL-15 and TGF beta for 14 days. Both day 1 TCM and matured day 14 TRM-like cells were further processed using the 5´10X genomics workflow.

2023-06-12 | E-MTAB-12840 | biostudies-arrayexpress

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