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Cellular origin and clonal evolution of human dedifferentiated liposarcoma

ABSTRACT: Cellular origin and clonal evolution of human dedifferentiated liposarcoma

PROVIDER: PRJNA914687 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22845316_1.fastq.gz	Fastqsanger.gz
	SRR22845316_2.fastq.gz	Fastqsanger.gz
	SRR22845317_1.fastq.gz	Fastqsanger.gz
	SRR22845317_2.fastq.gz	Fastqsanger.gz
	SRR22845318_1.fastq.gz	Fastqsanger.gz

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Cellular origin and clonal evolution of human dedifferentiated liposarcoma

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Cellular origin and clonal evolution of human dedifferentiated liposarcoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-22 | GSE221494 | GEO

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Project description:An integrated profiling approach was performed to define molecular alterations associated to the aggressive behavior of retroperitoneal dedifferentiated liposarcoma. In particular, matched well and dedifferentiated components as well as normal adipose tissues, obtained from the same tumor sites, were comparatively investigated to higlight differences in gene expression.

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Project description:Dedifferentiated liposarcoma (DDL) has the same cellular and molecular genetics features as well-differentiated liposarcoma (WDL), and there is still no ideal biomarker for the prediction of DDL patient prognosis in clinical practice. In order to explore the genes that cause WDL to obtain local invasion and distant metastasis capacities and transform it into DDL, The four DDL tissue specimens in this study were matched with four WDL tissue specimens according to baseline characteristics, such as gender, age, and recurrence, before high-throughput sequencing was conducted. Then total RNAs were subjected to RNA isolation and RNA-seq analyses were generated by deep sequencing using Illumina Hiseq.

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