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Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (Ribo-Seq)

ABSTRACT: Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (Ribo-Seq)

PROVIDER: PRJNA915110 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22874905.fastq.gz	Fastqsanger.gz
	SRR22874906.fastq.gz	Fastqsanger.gz
	SRR22874907.fastq.gz	Fastqsanger.gz
	SRR22874908.fastq.gz	Fastqsanger.gz

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Similar Datasets

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (Ribo-Seq)

Project description:Adult skeletal muscle stem cells, also known satellite cells (SCs), are quiescent and activate in response to injury. However, the activation mechanisms of quiescent SCs (QSCs) remain largely unknown. Here, we investigated the metabolic regulation of SC activation by identifying regulatory metabolites that promote SC activation. Using targeted metabolomics, we found that spermidine acts as a regulatory metabolite to promote SC activation and muscle regeneration in mice. Mechanistically, spermidine activates SCs via generating hypusinated eIF5A. Using SC-specific eIF5A-knockout (KO) and Myod-KO mice, we further found that eIF5A is required for spermidine-mediated SC activation by controlling MyoD translation. More significantly, depletion of eIF5A in SCs results in impaired muscle regeneration in mice. Together, the findings of our study define a novel mechanism that is essential for SC activation and acts via spermidine-eIF5A-mediated MyoD translation. Our findings suggest that the spermidine-eIF5A axis represents a promising pharmacological target in efforts to activate endogenous SCs for the treatment of muscular disease.

2024-10-08 | GSE221640 | GEO

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (scRNA-Seq)

2024-10-08 | GSE221642 | GEO

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (Polysome-Seq)

2024-10-08 | GSE221639 | GEO

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (RNA-Seq)

2024-10-08 | GSE221641 | GEO

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control

Project description:Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control

| PRJNA915107 | ENA

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (scRNA-Seq)

Project description:Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (scRNA-Seq)

| PRJNA915112 | ENA

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (Polysome-Seq)

Project description:Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (Polysome-Seq)

| PRJNA915109 | ENA

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (RNA-Seq)

Project description:Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control (RNA-Seq)

| PRJNA915111 | ENA

Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control.

| S-EPMC11383958 | biostudies-literature

Spermidine restricts neonatal inflammation via metabolic shaping of PMN-MDSCs [CUT&Tag]

Project description:Newborns exhibit a heightened vulnerability to inflammatory disorders due to their underdeveloped immune system, yet the underlying mechanisms remain poorly understood. Here we report that plasma spermidine is correlated with the maturity of human newborns and reduced risk of inflammation. Administration of spermidine led to the remission of neonatal inflammation in mice. Mechanistic studies revealed that spermidine enhanced the generation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) via downstream eIF5A hypusination (eIF5A-Hyp). Genetic deficiency or pharmacological inhibition of deoxyhypusine synthase (DHPS), a key enzyme of eIF5A-Hyp, diminished the immunosuppressive activity of PMN-MDSCs, leading to aggravated neonatal inflammation. The eIF5A-Hyp pathway was found to enhance mitochondrial function via histone acetylation-mediated epigenetic transcription of immunosuppressive signatures in PMN-MDSCs. These findings demonstrated spermidine-eIF5A-Hyp metabolic axis as a master switch to restrict neonatal inflammation.

2025-04-09 | GSE287179 | GEO

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