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Genomic resources enable study of the blastoclad fungus, Coelomomyces lativittatus, an obligate parasite of mosquitoes and microcrustaceans, during infection and sporulation

ABSTRACT: Genomic resources enable study of the blastoclad fungus, Coelomomyces lativittatus, an obligate parasite of mosquitoes and microcrustaceans, during infection and sporulation

PROVIDER: PRJNA918605 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22985200_1.fastq.gz	Fastqsanger.gz
	SRR22985200_2.fastq.gz	Fastqsanger.gz
	SRR22985201_1.fastq.gz	Fastqsanger.gz
	SRR22985201_2.fastq.gz	Fastqsanger.gz
	SRR22985202_1.fastq.gz	Fastqsanger.gz

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Genomic resources enable study of the blastoclad fungus, Coelomomyces lativittatus, an obligate parasite of mosquitoes and microcrustaceans, during infection and sporulation

Project description:Blastocladiomycota, early diverging zoosporic (flagellated) lineages of fungi, are vastly understudied. This phylum includes the genus Coelomomyces which consists of more than eighty fungal species that are obligate parasites of arthropods. Coelomomyces lack a complete asexual life cycle, instead surviving through an obligate heteroecious alternation of generations life cycle. Despite their global distribution and interesting life cycle, little is known about Coelomomyces species. To begin to address this, we analyzed transcriptomes from across host-associated life stages including infection of larva and excised mature sporangia from the mosquito, Anopheles quadrimaculatus. We identified differentially expressed genes and over-enriched GO terms both across and within life stages and used these to make hypotheses about C. lativittatus biology. Generally, we found the C. lativittatus transcriptome to be a complex and dynamic expression landscape; GO terms related to metabolism and transport processes were over-enriched during infection and terms related to dispersal were over-enriched during sporulation. The C. lativittatus transcriptomes reported here are a valuable resource and may be leveraged toward furthering understanding of the biology of these and other early diverging fungal lineages.

2023-01-21 | GSE222209 | GEO

Coelomomyces lativittatus

Project description:Coelomomyces lativittatus overview

| PRJNA373777 | ENA

Coelomomyces lativittatus strain:ClRM-AVA-1

Project description:Coelomomyces lativittatus ClRM-AVA-1 Transcriptome

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Coelomomyces lativittatus strain:ClRM-AVA-1

Project description:Coelomomyces lativittatus ClRM-AVA-1 Standard Draft genome sequencing

| PRJNA334352 | ENA

Coelomomyces lativittatus strain:CIRM-AVA-1-Amber

Project description:Coelomomyces lativittatus CIRM-AVA-1-Amber Genome sequencing and assembly

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Coelomomyces lativittatus strain:CIRM-AVA-1-Orange

Project description:Coelomomyces lativittatus CIRM-AVA-1-Orange Genome sequencing and assembly

| PRJNA631429 | ENA

Coelomomyces lativittatus strain:CIRM-AVA-1-Meiospore

Project description:Coelomomyces lativittatus CIRM-AVA-1-Meiospore Genome sequencing and assembly

| PRJNA631430 | ENA

A network of small RNAs regulates sporulation initiation in C. difficile

Project description:The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues, and molecular mechanisms regulating sporulation initiation remain ill defined. Here, using RIL-seq to capture the Hfq-dependent RNA-RNA interactome, we discovered a network of small RNAs that bind to mRNAs encoding sporulation-related genes. We show that two of these small RNAs, SpoX and SpoY, regulate translation of the master regulator of sporulation, Spo0A, in an opposing manner, which ultimately leads to altered sporulation rates. Infection of antibiotic-treated mice with SpoX and SpoY deletion mutants revealed a global effect on gut colonization and intestinal sporulation. Our work uncovers an elaborate RNA-RNA interactome controlling the physiology and virulence of C. difficile and identifies a complex post-transcriptional layer in the regulation of spore formation in this important human pathogen.

2022-12-31 | GSE213005 | GEO

Sporulation: TAO3 replacement strains

Project description:Sporulation: TAO3 replacement strains

| PRJEB8698 | ENA

Elongation Factor P is important for sporulation initiation

Project description:The universally conserved protein Elongation Factor P facilitates translation at amino acids that form peptide bonds with low efficiency, particularly poly-proline tracts. Despite its wide conservation, it is not essential in most bacteria and its physiological role remains unclear. Here, we show that EF-P affects the process of sporulation initiation in the bacterium Bacillus subtilis. We observe that lack of EF-P delays expression of sporulation-specific genes. Using ribosome profiling, we observe that expression of spo0A, encoding a transcription factor that functions as the master regulator of sporulation, is lower in a ∆efp strain as compared to the wildtype. Ectopic expression of Spo0A rescues the sporulation initiation phenotype, indicating that reduced spo0A expression explains the sporulation defect in ∆efp cells. Since Spo0A is the earliest sporulation transcription factor, these data suggest that sporulation initiation can be delayed when protein synthesis is impaired.

2023-01-04 | GSE222121 | GEO

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