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Erucic acid improves the pregnancy complicated with systemic lupus erythematosus by inhibiting the effector function of CD8+ T cell

ABSTRACT: Erucic acid improves the pregnancy complicated with systemic lupus erythematosus by inhibiting the effector function of CD8+ T cell

PROVIDER: PRJNA922547 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23037536_1.fastq.gz	Fastqsanger.gz
	SRR23037536_2.fastq.gz	Fastqsanger.gz
	SRR23037537_1.fastq.gz	Fastqsanger.gz
	SRR23037537_2.fastq.gz	Fastqsanger.gz
	SRR23037538_1.fastq.gz	Fastqsanger.gz

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Erucic acid improves the pregnancy complicated with systemic lupus erythematosus by inhibiting the effector function of CD8+ T cell

Project description:Pathogenic CD8+ T cells are closely related to the development of systemic lupus erythematosus. Erucic acid (EA) has been proved to have anti-inflammatory activity. However, whether EA can regulate pathogenic CD8+ T cells function in pregnancy complicated with systemic lupus erythematosus (pSLE) has not been investigated. In our study, we detected enhanced CD8+ T cell effector function and decreased EA levels in patients with pSLE compared to healthy pregnancy control. Plasma EA levels were negatively correlated with the severity complications of pSLE. In blood from patients with pSLE, EA inhibited the effector function of CD8+ T cells and the maintenance of stem cell-like memory CD8+ T cells. Mechanically, EA inhibited STAT3 phosphorylation and promoted ferroptosis, which contributed directly to the attenuated effector function of CD8+ T cells in pSLE. Moreover, EA supplementation in pregnant MRL/lpr mice inhibited the effector function of uterine CD8+ T cells and alleviated placental pathological damage. Our findings reveal the modulatory effects of EA on pathogenic CD8+ T cells from an immune response perspective, thus providing new insights into therapeutic strategy for patients with pSLE.

2025-01-01 | GSE222565 | GEO

Blood immunomonitoring uncovers pregnancy-induced immune programs and their dysregulation in lupus pregnancy destined for complications

Project description:Systemic lupus erythematosus carries increased risk of pregnancy complications. To understand the underlying molecular mechanisms, we characterized the blood transcriptome of lupus patients and healthy controls during pregnancy and postpartum and performed multicolor flow-cytometry in a subset. We also followed healthy women undergoing assisted reproductive technology, allowing for analysis around embryo implantation. A striking and sustained down modulation of two lupus-related signatures, interferon and plasma cells, takes place during healthy pregnancy. These changes appear immediately post embryo implantation and are mirrored in uncomplicated lupus pregnancies. Patients with preeclampsia displayed early upregulation of neutrophil signatures and expansion of immature neutrophils. Lupus pregnancies with fetal complications carried the highest interferon and plasma cell signatures as well as ICOS+ CD4+ T cell counts. Thus, healthy and uncomplicated lupus pregnancies exhibit early and sustained transcriptional modulation of lupus-related signatures, and failure to do so is associated with adverse outcomes.

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Project description:Systemic lupus erythematosus

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Project description:We performed spatial transcriptomics on a case series of different clinical subtypes of cutaneous lupus erythematosus including acute cutaneous lupus erythematosus (malar rash, systemic lupus erythematosus). Our goals were to (1) determine which differentially expressed genes (DEGs) could be attributed to specific cell populations in specific locations within the tissue, (2) determine if spatial transcriptomics could better distinguish between CLE clinical subtypes than bulk RNA approaches and (3) examine potential cell-cell communication pathways within the skin lesions.

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