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Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila [CUT&RUN]

ABSTRACT: Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila [CUT&RUN]

PROVIDER: PRJNA923258 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23060912_1.fastq.gz	Fastqsanger.gz
	SRR23060912_2.fastq.gz	Fastqsanger.gz
	SRR23060913_1.fastq.gz	Fastqsanger.gz
	SRR23060913_2.fastq.gz	Fastqsanger.gz

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Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila [greenCUT&RUN]

Project description:Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila [greenCUT&RUN]

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Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila [ATAC-seq]

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Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila [CUT&RUN]

Project description:The loss of discrete morphological traits, the most common evolutionary transition, is typically driven by changes in expression of developmental genes. Mutations accumulating in regulatory elements of these genes can disrupt DNA binding sites for transcription factors patterning their spatial expression, or delete entire enhancers. Regulatory elements, however, may in principle be silenced through other mechanisms, including changes in chromatin accessibility, or the emergence of repressive elements. Here, we show that an increase in chromatin accessibility at the pigmentation gene yellow, combined with the gain of a repressor site, underlie the evolutionary loss of a spot pigmentation pattern on the wings of a Drosophila species. The evolutionary gain of accessibility of this repressive element is regulated by E93, a transcription factor governing the progress of metamorphosis. This convoluted evolutionary scenario contrasts with the classical parsimonious mutational paths generally envisioned and often documented for morphological losses. It illustrates for the first time how evolutionary changes in chromatin accessibility may directly contribute to morphological diversification.

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Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver [CUT&RUN]

Project description:Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile. However, little is known about the changes on the level of transcriptional regulation. Here, we used a multi-omics approach and integrated ATAC-, RNA- and NET-seq to identify age-related changes in the chromatin landscape of murine liver and to investigate how these are linked to transcriptional regulation. We provide the first systematic inventory of the connection between aging, chromatin accessibility and transcriptional regulation in a whole tissue. Aging in murine liver is characterized by an increase in chromatin accessibility at promoter regions, but not in an increase of transcriptional output. Instead, aging is accompanied by a decrease of promoter-proximal pausing of RNA polymerase II (Pol II), while initiation of transcription is not decreased as assessed by RNA polymerase mapping using CUT&RUN. Based on the data reported we propose that these age-related changes in transcriptional regulation are due to a reduced stability of the pausing complex.

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Increased chromatin accessibility promotes the evolution of a transcriptional silencer in <i>Drosophila</i>.

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