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Mutational analysis of PC9 and PC9-OR cell lines. [JXQ_WES]

ABSTRACT: Mutational analysis of PC9 and PC9-OR cell lines. [JXQ_WES]

PROVIDER: PRJNA924693 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23097260_1.fastq.gz	Fastqsanger.gz
	SRR23097260_2.fastq.gz	Fastqsanger.gz
	SRR23097261_1.fastq.gz	Fastqsanger.gz
	SRR23097261_2.fastq.gz	Fastqsanger.gz
	SRR23097262_1.fastq.gz	Fastqsanger.gz

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Gene expression of PC9 and PC9-OR cell line [JXQ_RNA]

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RNA Sequencing Analysis of NCAPD2 Knockdown in Lung Adenocarcinoma Cell Line PC9

Project description:This study investigates the effect of NCAPD2 knockdown on lung adenocarcinoma (LUAD) by performing RNA sequencing on PC9 cell lines. The experiment included three control PC9 cells and three PC9 cells in which NCAPD2 was knocked down using shRNA. This RNA sequencing experiment aims to elucidate the role of NCAPD2 in regulating gene expression associated with tumor proliferation, migration, and survival in LUAD. Analysis of differential gene expression provides insights into the pathways affected by NCAPD2 knockdown, with an emphasis on signaling pathways critical to LUAD progression, such as the PI3K/AKT pathway.

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The N6-methyadenosine (m6A) levels in PC9 cell lines.

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Transcriptome analysis of PC9 cells with gefitinib or/and hypoxia treatment and comparison with gefitinib resistant PC9 cells and ALDH positive PC9 cells

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Mutational analysis of PC9 and PC9-OR cell lines. [JXQ_WES]

Project description:To investigate if there are new genetic mutations occurred within the PC-9 osimertinib resistant cells compared with the parental cells.

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Gene expression of PC9 and PC9-OR cell line [JXQ_RNA]

Project description:Gene expression of PC9 and PC9-OR cell line [JXQ_RNA]

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Single cell RNA sequencing analysis of freshly resected PC9 cell line-derived tumor xenografts

Project description:The non-small cell lung carcinoma (NSCLC) PC9 cell line is an established preclinical model for tyrosine kinase inhibitors. Using PC9 cells, we generated EGFR-mutant lung cancer xenografts to study the differences in response between individual cells and cell populations. We performed treatment of PC9 xenograft tumors with the combination of osimertinib and crizotinib as well as single drugs, followed by Drop-seq. The addition of crizotinib was guided by our previous data in PC9 grown in cell culture that identified an erlotinib-resistant drug population sensitive to crizotinib. The results of the xenograft study show that combination treatment targets specific osimertinib-tolerant cell populations but leaves a subset of the population that is tolerant to the combo. Each cell subpopulation is characterized by specific molecular signatures. The results of our study help to address emerging drug resistance that limits clinical usefulness of targeted strategies, particularly in NSCLC.

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