Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Extracellular microRNA: Novel Biomarker and Potential Therapeutic Target in Trauma

ABSTRACT: Extracellular microRNA: Novel Biomarker and Potential Therapeutic Target in Trauma

PROVIDER: PRJNA925146 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23118447.fastq.gz	Fastqsanger.gz
	SRR23118448.fastq.gz	Fastqsanger.gz
	SRR23118449.fastq.gz	Fastqsanger.gz
	SRR23118450.fastq.gz	Fastqsanger.gz
	SRR23118451.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 35

Similar Datasets

Extracellular microRNA: Novel Biomarker and Potential Therapeutic Target in Trauma

Project description:Based on our animal studies, we propose that circulating miRNAs are released from injured tissues after trauma. We use small RNA sequencing to characteriza plasma miRNA in trauma and healthy control patients and trauma and control mice

2023-03-22 | GSE223151 | GEO

Small extracellular vesicles propagate the inflammatory response after trauma.

Project description:Small extracellular vesicles propagate the inflammatory response after trauma.

| PRJNA722432 | ENA

Surgical trauma in mice modifies the content of circulating extracellular vesicles

Project description:Surgical trauma in mice modifies the content of circulating extracellular vesicles

| PRJNA785446 | ENA

MicroRNA-138: A Diagnostic Biomarker and Therapeutic Target for the Aggressive Basal-like subtype of Breast Cancer

Project description:This study identifies miR-138 as a prognostic biomarker for basal breast carcinoma. Identification of differentially regulated genes upon miR-138 knockdown (AntagomiR-138) in basal breast cancer cell lines MDA-MB-231

2020-04-13 | GSE110659 | GEO

c-MET as a potential therapeutic target and biomarker in cancer.

Project description: Not available

| S-EPMC3225018 | biostudies-other

Keratinocyte-derived circulating microRNAs in extracellular vesicles: a novel biomarker of psoriasis severity and potential therapeutic target.

Project description: Not available

| S-EPMC10910723 | biostudies-literature

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.

Project description: Not available

| S-EPMC3638905 | biostudies-literature

Burn/Trauma Study

Project description:#G017 Burn/Trauma Study. This is a Glue Grant Study comparison between gene expression analyses performed in eight trauma/burn subjects using either a buffy coat isolation of whole blood or using the PAXgene system Keywords: other

2004-04-24 | GSE1343 | GEO

MicroRNA-34a: a potential therapeutic target in human cancer.

Project description: Not available

| S-EPMC4123066 | biostudies-literature

The spatially resolved kidney transcriptome signatures in rat models of trauma-induced acute kidney injury

Project description:Acute kidney injury (AKI) is a severe complication of trauma, particularly in cases involving hemorrhagic shock (HS) and rhabdomyolysis (RM). To elucidate the molecular mechanisms underlying trauma-induced AKI, we developed three rat models: HS, RM, and their combination (RM-HS). RM-HS resulted in the most severe phenotype, including high mortality, profound metabolic dysfunction, and extensive renal injury. Bulk and spatial transcriptomics revealed RM as the dominant driver of transcriptional changes, with significant involvement of hypoxia, reactive oxygen species (ROS), unfolded protein response (UPR), and apoptosis pathways. Region-specific analyses highlighted the corticomedullary junction (CMJ) as a critical site of injury, where lipid metabolism dysregulation and ferroptosis were prominent. Notably, perilipin 2 (PLIN2) emerged as a key marker of RM and RM-HS, correlating with metabolic dysfunction and injury severity. These findings provide mechanistic insights into trauma-induced AKI and identify PLIN2 as a potential biomarker and therapeutic target for mitigating kidney damage in trauma patients.

2026-05-15 | GSE293015 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data