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Genome-wide maps of transcription in Multiple Myeloma cells treated with FHND004 or FHND008

ABSTRACT: Genome-wide maps of transcription in Multiple Myeloma cells treated with FHND004 or FHND008

PROVIDER: PRJNA925161 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23111100_1.fastq.gz	Fastqsanger.gz
	SRR23111100_2.fastq.gz	Fastqsanger.gz
	SRR23111101_1.fastq.gz	Fastqsanger.gz
	SRR23111101_2.fastq.gz	Fastqsanger.gz
	SRR23111102_1.fastq.gz	Fastqsanger.gz

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Genome-wide maps of transcription in Multiple Myeloma cells treated with FHND004 or FHND008

Project description:FHND004 and FHND008 are newly synthesized epidermal growth factor receptor (EGFR) inhibitor for the treatment of non-small cell lung cancer (NSCLC), they were obtained on the basis of AZD9291. We found that FHND004 and FHND008 had a strong inhibitory effect on the proliferation of multiple myeloma cells in vitro. Genome-wide maps of transcription showed different genes change in Multiple Myeloma cells after 4μM FHND004 or FHND008 intervention.

2024-04-03 | GSE223166 | GEO

Genome-wide maps of transcription in GART overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:Genome-wide maps of transcription in GART overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

| PRJNA923677 | ENA

Genome-wide maps of transcription in PNPO overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:Genome-wide maps of transcription in PNPO overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

| PRJNA750421 | ENA

Genome-wide maps of transcription in DEAF1 overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:Genome-wide maps of transcription in DEAF1 overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

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Multiple myeloma

Project description:Multiple myeloma

| PRJNA515992 | ENA

Genome-wide maps of chromatin state in DEAF1 overexpression (OE in Multiple Myeloma)

Project description:Genome-wide maps of chromatin state in DEAF1 overexpression (OE in Multiple Myeloma)

| PRJNA738501 | ENA

Multiple Myeloma cells

Project description:Multiple Myeloma cells

| PRJNA800411 | ENA

Genome-wide maps of chromatin state in YTHDF2 kockdown(KD) and wildtype(WT) cells in Multiple Myeloma

Project description:We found that the experssion of STAT5A was upregulated when the YTHDF2 was knocked down. To identify the function of STAT5A protein as a Transcription factor in YTHDF2 kockdown(KD) and wildtype(WT) cells in Multiple Myeloma. CHIP-seq was conducted to analyze changes in related signaling pathways and gene expression in Multiple Myeloma cells when YTHDF2 was knocked down.

2022-06-30 | GSE163138 | GEO

Serum protein N-glycosylation changes in multiple myeloma

Project description:<h4><strong>BACKGROUND:</strong> Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies only detected limited serum N-glycan features.</h4><h4><strong>METHODS:</strong> Here, a more detailed study of the human serum N-glycome of 91 multiple myeloma patients and 51 controls was performed. We additionally analyzed sequential samples from patients (n = 7) which were obtained at different time points during disease development as well as 16 paired blood serum and bone marrow plasma samples. N-glycans were enzymatically released and measured by mass spectrometry after linkage specific derivatization of sialic acids.</h4><h4><strong>RESULTS:</strong> A decrease in both α2,3- and α2,6-sialylation, galactosylation and an increase in fucosylation within complex-type N-glycans were found in multiple myeloma patients compared to controls, as well as a decrease in difucosylation of diantennary glycans. The observed glycosylation changes were present in all ISS stages, including the 'low-risk' ISS I. In individual patients, difucosylation of diantennary glycans decreased with development of the disease. Protein N-glycosylation features from blood and bone marrow showed strong correlation. Moreover, associations of monoclonal immunoglobulin (M-protein) and albumin levels with glycan traits were discovered in multiple myeloma patients.</h4><h4><strong>CONCLUSIONS & GENERAL SIGNIFICANCE: </strong>In conclusion, serum protein N-glycosylation analysis could successfully distinguish multiple myeloma from healthy controls. Further studies are needed to assess the potential roles of glycan trait changes and the associations of glycans with clinical parameters in multiple myeloma early detection and prognosis.</h4>

2022-04-27 | MTBLS676 | MetaboLights

Genome-wide identification of 5hmCpGs in multiple myeloma

Project description:We report the genomic localization of 5-hydroxymethylcytosines in multiple myeloma patients through the use of selective chemical labeling (SCL) and exonuclease digestion. Data highlighted super-enhancers and enhancers specifically undergoing active DNA demethylation in multiple myeloma cells.

2019-07-08 | GSE124188 | GEO

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