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Effect of DNA G-quadruplex binder on tumor cell line SAS

ABSTRACT: Effect of DNA G-quadruplex binder on tumor cell line SAS

PROVIDER: PRJNA925560 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23136746_1.fastq.gz	Fastqsanger.gz
	SRR23136746_2.fastq.gz	Fastqsanger.gz
	SRR23136747_1.fastq.gz	Fastqsanger.gz
	SRR23136747_2.fastq.gz	Fastqsanger.gz
	SRR23136748_1.fastq.gz	Fastqsanger.gz

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Effect of DNA G-quadruplex binder on tumor cell line SAS

Project description:A new group of G-quadruplex binder, cyclic anthraquinone derivative which named cAQ-mBen was developed for G-quadruplex specific recognition. We used RNA-Seq to explore the effect of cAQ-mBen and anthraquinone derivative which named AQ-ac on the whole-transcriptome profiles of tumor cell line SAS.

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SAS shKDM4C cell line RNA sequencing

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Project description:This study uses RNA-seq analysis to explore the impact of KDM4C, a histone lysine demethylase, on head and neck squamous cell carcinoma (HNSCC). KDM4C modifies histone proteins by removing methyl groups from H3K9me3/2, which affects gene expression. The study focuses on the role of KDM4C in SAS cells, a type of HNSCC cell line, specifically concerning metastasis. Gene Set Enrichment Analysis analyzed RNA-seq data comparing SAS cells with and without KDM4C depletion (sh4C#1 vs. LKO). The result showed that KDM4C significantly influences various metabolic processes, including heme metabolism, peroxisome function, and bile acid metabolism in SAS cells. Additionally, the study performed a KDM4C-ChIP seq analysis on SAS cells to gain further insight into its role. According to Enrichr analysis, GATA1 was the top-ranking transcription factor in these pathways, suggesting its potential interaction with KDM4C in HNSCC.

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SAS cell line ChIP and RNA-seq

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Silencing of HAI-1 in a human oral squamous cell carcinoma cell line, SAS

Project description:To examine the role of hepatpcyte growth factor activator inhibitor type 1 (HAI-1) in cancer, we analyzed effect of HAI-1 silencing on gene expression profiles of human oral squamous cell carcinoma cell line, SAS. We used short hairpin RNA (shRNA) directed against HAI-1 mRNA. We constructed retroviral vectors which showed stable and significant silencing effects on HAI-1 genes of SAS. Microarray data of the expression profiles of duplicated experiments of HAI-1-knockdown SAS with that from the control cell are shown.

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RNA-seq Analysis of with/without overexpression of ASC in SAS cell line

Project description:To investigate the genes regulated by ASC, we generated the RNA-seq data of oral cancer cell line SAS with/without overexpression of ASC gene .

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Human tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling

2016-02-28 | GSE44766 | GEO

Gene expression signatures for eSAS (human tongue squamous-cell carcinoma cell line) compared with parental SAS

Project description:To examine if gene expression level is altered in eSAS (human tongue squamous-cell carcinoma cell line) compared with that of parental SAS, we performed genome-wide DNA microarray analysis. For this purpose, we prepared total mRNAs from SAS and eSAS cells in their Log growth phase and compared their genome-wide expression levels.

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Human tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling

Project description:Transcriptional profiling of SAS cells transfected with pLKO.1-LYRIC shRNA-B expression vector (desinaged as B) and control SAS cells (transfected with pLKO.1 vector, designated as CTL). Goal was to determine the effects of LYRIC knockdown on global SAS cells gene expression. Two-condition experiment, SAS cells transfected with pLKO.1-LYRIC shRNA-B expression vector (desinaged as B) v.s. control SAS cells (transfected with pLKO.1 vector, designated as CTL). Biological replicates: 4 control replicates, 4 transfected replicates.

2016-02-28 | E-GEOD-44766 | biostudies-arrayexpress

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