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Knockout of the B1 subunit of the GA-binding protein (GABP) [ChIP-seq]

ABSTRACT: Knockout of the B1 subunit of the GA-binding protein (GABP) [ChIP-seq]

PROVIDER: PRJNA929997 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23291182_1.fastq.gz	Fastqsanger.gz
	SRR23291182_2.fastq.gz	Fastqsanger.gz
	SRR23291183_1.fastq.gz	Fastqsanger.gz
	SRR23291183_2.fastq.gz	Fastqsanger.gz
	SRR23291184_1.fastq.gz	Fastqsanger.gz

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Knockout of the B1 subunit of the GA-binding protein (GABP)

Project description:Knockout of the B1 subunit of the GA-binding protein (GABP)

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Knockout of the B1 subunit of the GA-binding protein (GABP) [RNA-seq]

Project description:Knockout of the B1 subunit of the GA-binding protein (GABP) [RNA-seq]

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Knockout of the B1 subunit of the GA-binding protein (GABP) [RNA-seq]

Project description:We knocked out different exons corresponding to different sections of GABP, a transcription factor known to bind to the telomerase reverse transcriptase (TERT) promoter with the G228 mutation. We investigated the effects of the knockouts in the regulation of TERT expression and other subunits of GABP. GABP genomic binding sites were determined through chromatin immunoprecipitation sequencing (ChIP-seq), and gene expression was determined through total RNA sequencing (RNA-seq). Combining data pertaining to GABP binding sites and gene expression provided insight into the molecular mechanisms of maintaining the length of telomeres in cancers.

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Knockout of the B1 subunit of the GA-binding protein (GABP) [ChIP-seq]

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Knockout of the B1 subunit of the GA-binding protein (GABP)

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-06-11 | GSE224166 | GEO

RNA-seq identified GLI1 as the target gene for GABP

Project description:We performed RNA-seq based transcriptomic analysis to evaluate differential protein expression in the kidneys of GABP overexpressing mice in db/m and GABP knockdown mice in db/db. The cluster analysis heat map shows the genetic changes . Compared with db/m mice, 734 differentially expressed genes, 525 upregulated genes and 209 upregulated genes . Compared with db/db mice, 82 genes were up-regulated and 82 genes were down-regulated in the kidneys of mice with GABP knockdown in db/db . Further, the classical pathway map in IPA database found that cell growth, proliferation, organ development and other pathways were activated after GABP overexpression. Cell growth, proliferation, organ development and other pathways were inhibited . It was further confirmed that GABP was associated with proliferation. Among differentially expressed genes, there were 9 differentially expressed genes up-regulated by GABP overexpression and down-regulated by GABP knockdown . Through the analysis of Ingenuity Pathway Analysis database, GABP and GLI1 were most closely related .

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Effects of GABP knockdown on the transcriptome of macaque fibroblast cells

Project description:We identified a total of 2,058 GABP-regulated genes (1,067 up-regulated and 991 down-regulated genes in the GABP knockdown cells) with the threshold of Padj < 0.05 and Fold change > 1.5.

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Gene expression in GABPα-sufficient and -deficient T cells

Project description:Ets family transcription factor GA-binding protein (GABP) regulates gene expression in CD4 and CD8 T cells. We used microarray to examine genes differentially expressed in GABP-sufficient (WT) and GABP-deficient (KO) CD4 and CD8 T cells

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Genome-wide mapping of the transcription factor GABP-alpha binding in human CD34+CD133+ hematopoietic progenitor cells.

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Genome-wide mapping of the transcription factor GABP-alpha binding in human CD34+CD133+ hematopoietic progenitor cells.

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