Project description:We compared gene expression from 2C::tomato+/- ES cells from Kdm1a wt and mutant ES cultures 2C::tomato- samples 1, 5, 9 2C::tomato+ samples 2, 6, 10 We collecteded 3 replicates of RNA from 2C::tomato+ and - ES cells

2012-06-17 | E-GEOD-33763 | biostudies-arrayexpress

Little Sippewissett Marsh sediment cores

Project description:Little Sippewissett Marsh sediment cores Targeted loci environmental

| PRJNA1088085 | ENA

Biofilter

Project description:Biofilter Metagenome

| PRJNA521667 | ENA

Escherichia phage 11B

Project description:Escherichia phage 11B Assembly

| PRJNA564219 | ENA

Acidothermus cellulolyticus 11B isolate:ATCC 43068

Project description:Acidothermus cellulolyticus 11B methylation - 11B epigenomics

| PRJNA568273 | ENA

biofilter metagenome

Project description:Biofilter Metagenome

| PRJNA182594 | ENA

Genetics, energetics, and allostery in proteins with randomized cores and surfaces

Project description:A lack of systematic experimental data limits our understanding of protein evolution. In this study, we experimentally characterized proteins with randomized sequences. Vast numbers of amino acid combinations constitute stable protein cores and surfaces. However, alternative cores frequently disrupt protein function by indirect allosteric effects. Both protein stability and binding can be predicted by using simple additive energy models with a small contribution from pairwise energetic couplings. Indeed, energy models trained on one protein can predict functional cores and surfaces across more than a billion years of evolution, with only rare energetic couplings that we experimentally identify limiting the transplantation of cores between highly diverged proteins. Our results reveal the simple energetic architecture of proteins and suggest that allostery is an important constraint on sequence evolution.

2024-05-13 | GSE266299 | GEO

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