Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CITE-seq of Neuropilin 2-expressing CD4+ T cells [II]

ABSTRACT: CITE-seq of Neuropilin 2-expressing CD4+ T cells [II]

PROVIDER: PRJNA938099 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23602497.fastq.gz	Fastqsanger.gz
	SRR23602498.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

CITE-seq of Neuropilin 2-expressing CD4+ T cells

Project description:We report that Neuropilin 2 expressing human CD4+ cells are a unique population of dysfunctional T effector cells.

2025-05-02 | GSE225955 | GEO

Transcriptomic profiling of Neuropilin 2-expressing CD4+ T cells

Project description:We report a novel Neuropilin 2-expressing CD4+ T cell subset that modulates immune responses in vivo.

2025-05-02 | GSE225954 | GEO

Transcriptomic profiling of Neuropilin 2-expressing CD4+ T cells

Project description:Transcriptomic profiling of Neuropilin 2-expressing CD4+ T cells

| PRJNA967451 | ENA

Transcriptomic profiling of Neuropilin 2-expressing CD4+ T cells

Project description:Transcriptomic profiling of Neuropilin 2-expressing CD4+ T cells

| PRJNA938097 | ENA

Neuropilin-1+ vs. Neuropilin-1- CD8+ T cells from Plasmodium berghei ANKA-infected mice

Project description:Characterization of Neuropilin-1+ and Neuropilin-1- splenic CD8+ T cells from Plasmodium berghei ANKA-infected C57BL/6 mice

2022-12-31 | GSE199569 | GEO

CITE-seq of CD4+ T and myeloid cells in MS Twin cohort.

Project description:CITE-seq of CD4+ T and myeloid cells in MS Twin cohort.

| PRJNA795192 | ENA

Role of Neuropilin-1 in regulatory T cell stability and function

Project description:To investigate the function of Neuropilin-1 (NRP-1) in Foxp3+ regulatory T (Treg) cell stability and function, we cultured naïve CD4+ T cells under induced Treg cell (iTreg)-differentiating condition. We then flow sorted NRP-1+ and NRP-1- iTreg cells and performed gene expression profiling analysis.

2022-04-30 | GSE201416 | GEO

Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells.

Project description:Despite the decades-old knowledge that males and people with diabetes mellitus (DM) are at increased risk for coronary artery disease (CAD), the reasons for this association are only partially understood. Among the immune cells involved, recent evidence supports a critical role of T cells as drivers and modifiers of CAD. CD4+ T cells are commonly found in atherosclerotic plaques. We aimed to understand the relationship of CAD with sex and DM by single-cell RNA (scRNA-Seq) and antibody sequencing (CITE-Seq) of CD4+ T cells. Peripheral blood mononuclear cells (PBMCs) of 61 men and women who underwent cardiac catheterization were interrogated by scRNA-Seq combined with 49 surface markers (CITE-Seq). CAD severity was quantified using Gensini scores, with scores above 30 considered CAD+ and below 6 considered CAD-. Four pairs of groups were matched for clinical and demographic parameters. To test how sex and DM changed cell proportions and gene expression, we compared matched groups of men and women, as well as diabetic and non-diabetic subjects. We analyzed 41,782 single CD4+ T cell transcriptomes for sex differences in 16 women and 45 men with and without coronary artery disease and with and without DM. We identified 16 clusters in CD4+ T cells. The proportion of cells in CD4+ effector memory cluster 8 (CD4T8, CCR2+ Em) was significantly decreased in CAD+, especially among DM+ participants. This same cluster, CD4T8, was significantly decreased in female participants, along with two other CD4+ T cell clusters. In CD4+ T cells, 31 genes showed significant and coordinated upregulation in both CAD and DM. The DM gene signature was partially additive to the CAD gene signature. We conclude that (1) CAD and DM are clearly reflected in PBMC transcriptomes, and (2) significant differences exist between women and men and (3) between subjects with DM and non-DM.

| S-EPMC9456056 | biostudies-literature

Transcriptional profiling of LNGFR.FOXP3-expressing scurfy CD4+ T cells

Project description:Transcriptional profiling of LNGFR.FOXP3-expressing scurfy CD4+ T cells

| PRJNA698983 | ENA

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [CITE-seq]

Project description:Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma [CITE-seq]

| PRJNA974853 | ENA