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Effects of CRABP1 overexpression on thyroid cancer cell lines

ABSTRACT: Effects of CRABP1 overexpression on thyroid cancer cell lines

PROVIDER: PRJNA938419 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23610232_1.fastq.gz	Fastqsanger.gz
	SRR23610232_2.fastq.gz	Fastqsanger.gz
	SRR23610233_1.fastq.gz	Fastqsanger.gz
	SRR23610233_2.fastq.gz	Fastqsanger.gz
	SRR23610234_1.fastq.gz	Fastqsanger.gz

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Effects of CRABP1 overexpression on thyroid cancer cell lines

Project description:Cellular retinoic acid-binding protein 1 (CRABP1) is a cytosolic lipid-binding protein which is thought to play an important role in regulating retinoic acid signaling. Loss of CRABP1 expression has been observed in thyroid cancer. We transfected a CRABP1-overexpressing vector to thyroid cancer cells to elucidate its oncogenic effects.

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Project description:Purpose: The primary goal of this study was to identify gene-expression profiles of anaplastic thyroid cancer and to identify some novel in-frame gene fusions that could result in translated protein products affecting the development of anaplastic thyroid cancer. Methods: RNAseq Data was processed with TCGA UNC V2 RNAseq protocol and different expressed genes were identify by using DESeq2, limma-voom, and edgeR. Potential fusion genes were identified by using SOAPfuse, Chimerascan and TopHat-Fusion. Potential fusion genes were confirmed by cDNA PCR and Sanger sequencing. Results: A total of 21 fusion genes were detected, including six predicted in-frame fusions; none were recurrent. Global gene expression analysis showed 661 genes to be differentially expressed between anaplastic thyroid cancer and papillary thyroid cancer cell lines, with pathway enrichment analyses showing downregulation of TP53-signaling as well as cell adhesion molecules in anaplastic thyroid cancer . Conclusions: Our study represents the first detailed analysis of anaplastic thyroid cancer cell lines and found several novel in-frame gene fusions that could result in translated protein products affecting the development of anaplastic thyroid cancer. These data provide novel insights into the tumorigenesis of anaplastic thyroid cancer and may be used to identify new therapeutic targets.

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Project description:Anaplastic thyroid carcinoma (ATC) is a rare but deadly thyroid cancer. In contrast, papillary thyroid carcinoma (PTC) is common and highly curable. Minimally invasive biomarkers are needed to distinguish ATC and PTC. Here, by small RNA-seq we show the differential expression levels of several miRNAs, which include miR-34a and miR-210 in ATC compared to PTC cell lines.

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Papillary thyroid cancer cell lines treated with Y15

Project description:3 papillary thyroid cancer cell lines were compared, treated with Y15 to untreated.

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Project description:Cellular retinoic acid-binding protein 2, encoded by the CRABP2 gene, is a protein that facilitates retinoic acid binding to its cognate receptor complex and transport to the nucleus. Our analysis indicates that CRABP2 expression is upregulated in thyroid cancer and is involved in the invasiveness of thyroid cancer. Loss- and gain-of-function approaches were used to elucidate its oncogenic mechanisms.

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Papillary thyroid cancer cell lines treated with Y15

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