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Effect of NEK2 deficiency on gene expression of CD19-selected spleen B cells of Eμ-myc mouse model

ABSTRACT: Effect of NEK2 deficiency on gene expression of CD19-selected spleen B cells of Eμ-myc mouse model

PROVIDER: PRJNA941214 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23705216_1.fastq.gz	Fastqsanger.gz
	SRR23705216_2.fastq.gz	Fastqsanger.gz
	SRR23705217_1.fastq.gz	Fastqsanger.gz
	SRR23705217_2.fastq.gz	Fastqsanger.gz
	SRR23705218_1.fastq.gz	Fastqsanger.gz

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Effect of NEK2 deficiency on gene expression of CD19-selected spleen B cells of Eμ-myc mouse model

Project description:NEK2 overexpression in the B cell lineage affects B cell development. To determine whether deficiency of NEK2 inhibits B cell malignancies, we crossed Nek2 knockout mice with Eμ-myc transgenic mice, a well-established Myc-driven preclinical model for B cell malignancies. Three genotyping offsprings were obtained: Eμ-myc/Nek2+/+ (NEK2 wild type), Eμ-myc/Nek2+/- (NEK2 heterozygotes), and Eμ-myc/Nek2-/- (NEK2 homozygotes). Bulk RNA-seq was performed on CD19-selected spleen B cells to view the transcriptome differences.

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