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Transcriptomic profile of blood cells exposed to particulate matter

ABSTRACT: Transcriptomic profile of blood cells exposed to particulate matter

PROVIDER: PRJNA941263 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23707019.fastq.gz	Fastqsanger.gz
	SRR23707020.fastq.gz	Fastqsanger.gz
	SRR23707021.fastq.gz	Fastqsanger.gz
	SRR23707022.fastq.gz	Fastqsanger.gz
	SRR23707023.fastq.gz	Fastqsanger.gz

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Transcriptomic profile of blood cells exposed to particulate matter

Project description:Here we used next generation sequencing (NGS), to determine the transcriptional profile of blood cells exposed to particulate matter to contribute to the clarification of the importance of deregulated molecules in the molecular pathways involved in the inflammation. For this, blood cells from six adult healthy donors were treated with particulate matter.

2023-08-21 | GSE226707 | GEO

Cerebral cortex and blood transcriptome changes in mouse neonates prenatally exposed to air pollution particulate matter

Project description:Background: Prenatal exposure to air pollutants is associated with increased risk for neurodevelopmental and neurodegenerative disorders. However, few studies have identified transcriptional changes related to air pollutant exposure. Methods: RNA sequencing was used to examine transcriptomic changes in blood and cerebral cortex of three male and three female mouse neonates prenatally exposed to traffic-related nano-sized particulate matter (nPM) compared to three male and three female mouse neonates prenatally exposed to control filter air. Results: We identified 19 nPM-associated differentially expressed genes (nPM-DEGs) in blood and 124 nPM-DEGs in cerebral cortex. The cerebral cortex transcriptional responses to nPM suggested neuroinflammation involvement, including CREB1, BDNF, and IFN γ genes. Both blood and brain tissues showed nPM transcriptional changes related to DNA damage, oxidative stress, and immune responses. Three blood nPM-DEGs showed a canonical correlation of 0.98 with 14 nPM-DEGS in the cerebral cortex, suggesting a convergence of gene expression changes in blood and cerebral cortex. Exploratory sex-stratified analyses suggested a higher number of nPM-DEGs in female cerebral cortex than male cerebral cortex. The sex-stratified analyses identified 2 nPM-DEGs (Rgl2 and Gm37534) shared between blood and cerebral cortex in a sex-dependent manner. Conclusions: Our findings suggest that prenatal nPM exposure induces transcriptional changes in the cerebral cortex, some of which are also observed in blood. Further research is needed to replicate nPM-induced transcriptional changes with additional biologically relevant time points for brain development.

2021-08-25 | GSE142453 | GEO

Hippocampus and cortex of mice exposed to urban particulate matter

Project description:Urban particulate matter (UPM) is known to be a risk factor for respiratory and cardiovascular diseases, but recent studies report that UPM exposure is associated with the development of brain disorders. In this study, we performed bioinformatic analysis to elucidate the molecular mechanisms of the effects of UPM exposure on the brain.

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suspended particulate matter

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Particulate matter PM2.5

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Project description:This study aimed to shed light on the gene regulatory networks underlying plant leaf responses to air particulate matter. Our investigation focused on autochthonous shrubs of laurel (Laurus nobilis L.) grown in pots located in two contrasting areas: a highly polluted traffic road and rural countryside within the same town (Altopascio, Lucca, Italy). RNA-seq data were related to leaf morphological traits and air particulate matter, allowing to identify key players in modulating the capabilities of plants to phyllo-remediate high air particulate matter levels in urban environment.

2023-03-16 | E-MTAB-12332 | biostudies-arrayexpress

Transcription profiling by array of human alveolar leukocytes after subjects were exposed to wood smoke particulate matter or filtered air

Project description:Healthy human subjects were exposed to wood smoke particulate matter and filtered air on separate occasions. Alveolar leukocytes (predominantly macrophages) were then obtained and analysed by microarray to assess the impact of wood smoke on transcription in the airway.

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Project description:Genome-wide analysis of lncRNA expression profiles in COPD rat model exposed by cigarette smoking (CS) and fine particulate matter (PM2.5). Goal was to explore the differences and similarities lncRNAs expression in rats model of COPD exposed by CS and PM2.5.

2021-06-21 | GSE178513 | GEO

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Project description:This study aimed to shed light on the gene regulatory networks underlying plant leaf responses to air particulate matter. Our investigation focused on shrubs of Photinia x fraseri grown in pots located in two contrasting areas: a highly polluted traffic road and rural countryside within the same town (Altopascio, Lucca, Italy). RNA-seq data were related to leaf morphological traitsand air particulate matter, allowing to identify key players in modulating the capabilities of plants to phyllo-remediate high air particulate matter levels in urban environment.

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