Tissue DNA methylation during SIVmac infection in the rhesus macaque
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ABSTRACT:
PROVIDER: PRJNA942220 | ENA |
REPOSITORIES: ENA
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Project description:We characterized DNA methylation profiles across lentiviral infection in a progressing non-human primate model of AIDS - SIVmac infection in the rhesus macaque. We contrasted methylation data across the course of the SIVmac infection in the young adult and old adult rhesus macaques to identify potential age-related differential methylation patterns and epigenetic clock acceleration.
2025-06-18 | GSE226899 | GEO
Project description:We characterized DNA methylation profiles in blood PBMCs across lentiviral infection in a progressing non-human primate model of AIDS - SIVmac infection in the rhesus macaque. We contrasted methylation data across the course of the SIVmac infection in the young adult and old adult rhesus macaques to identify potential age-related differential methylation patterns and epigenetic clock acceleration.
2025-06-18 | GSE226858 | GEO
Project description:DNA methylation data from rhesus macaque (Macaca mulatta) profiled on the mammalian methylation array (HorvathMammalMethylChip40) which focuses on highly conserved CpGs across mammalian species. We profiled n = 283 tissue samples (blood, skin, adipose, kidney, liver, lung, muscle, and cerebral cortex)
2023-08-05 | GSE190664 | GEO
Project description:Methylation studies in rhesus macaque
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Project description:DNA methylation in PBMC during SIVmac infection in the rhesus macaque
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Project description:The primary goal of this study was to compare the performances of Rhesus Macaque Genome Array and Human Genome U133 Plus 2.0 Array with respect to the detection of differential expressions when rhesus macaque RNA extracts were labeled and hybridized. The secondary goal of this study was to investigate the effect of mismatch position on signal strength in Affymetrix GeneChips by examining naturally occurring mismatches between rhesus macaque transcripts and human probes from Human Genome U133 Plus 2.0 Array. The primary goal of this study was to compare the performances of Rhesus Macaque Genome Array and Human Genome U133 Plus 2.0 Array with respect to the detection of differential expressions when rhesus macaque RNA extracts were labeled and hybridized. The secondary goal of this study was to investigate the effect of mismatch position on signal strength in Affymetrix GeneChips by examining naturally occurring mismatches between rhesus macaque transcripts and human probes from Human Genome U133 Plus 2.0 Array. Keywords: cross hybridization Rhesus macaque RNA from five sources (immortalized fibroblasts, cerebral cortex, pancreas, testes and thymus) was divided into two sets of aliquots of equal amount. Samples from each of the five sources were labeled and hybridized with either Rhesus Macaque Genome Array or two Human Genome U133 Plus 2.0 Array. Rhesus macaque RNA from five sources (immortalized fibroblasts, cerebral cortex, pancreas, testes and thymus) was divided into two sets of aliquots of equal amount. Samples from each of the five sources were labeled and hybridized with either Rhesus Macaque Genome Array or two Human Genome U133 Plus 2.0 Array.
2008-06-15 | E-GEOD-9531 | biostudies-arrayexpress
Project description:This SuperSeries is composed of the following subset Series: GSE27459: Human cerebral cortex DNA methylation by MeDIP-Chip GSE27460: Rhesus macaque cerebral cortex DNA methylation profiling by MeDIP-Chip Refer to individual Series
2012-03-01 | E-GEOD-27461 | biostudies-arrayexpress
Project description:Sixteen individual rhesus macaque genomes were compared to a reference macaque genome (R354) on custom-designed sure-print 1M oligonucleotide microarray Agilent (Agilent Technologies) aCGH slide per manufacturer’s recommendations.
2011-05-11 | GSE19881 | GEO
Project description:Question Addressed: How does Simian immunodeficiency virus (SIV) infection alter gene expression in memory CD4 T cell subsets very early during the 1st 10 days after infection? Memory CD4 T cells were sorted from rhesus macaque peripheral blood samples before infection and then at 4 and 10 days post SIV infection. RNA was recovered from the sorted memory CD4 T cells samples. RNA from the time point prior to SIV infection from each individual animal was used as the reference for the post SIV infection time points for that same animal. Thus, for each data set, the 4 and 10 day time points are being directly compared to the pre-infection data from the same animal. RNA samples as indicated above were used for reverse transcription reactions that directly incorporate Cy5 and Cy3 labeled nucleotides into the cDNA. Time: Time after infection with SIV
2019-09-23 | GSE38917 | GEO
Project description:Sixteen individual rhesus macaque genomes were compared to a reference macaque genome (R354) on custom-designed sure-print 1M oligonucleotide microarray Agilent (Agilent Technologies) aCGH slide per manufacturer’s recommendations. a custom designed Agilent array-based comparative genomic hybridization (aCGH) platform, which comprises 950,843 unique 60-mer oligonucleotide probes specific to the rhesus macaque reference genome (rheMac2), to compare the genomic DNAs of 17 unrelated rhesus macaques of Indian origin to the genome of an unrelated sample from the same species.
2011-05-11 | E-GEOD-19881 | biostudies-arrayexpress